Title:
生体グルーの製造方法
Document Type and Number:
Japanese Patent JP3559568
Kind Code:
B2
Abstract:
A biological adhesive which, in aqueous solution does not spontaneously coagulate within an hour at 20 degrees C but which coagulates within 5 minutes following addition of calcium ions, is prepared by: (a) obtaining blood plasma; (b) obtaining a fibrinogen and coagulation factor-based biological adhesive from the plasma by known methods; and (c) optionally submitting the biological adhesive to lyophilisation. The plasma is contacted with a contact phase activator before or during (b). An apparatus for carrying out this process is also claimed, comprising a first container for receiving the plasma, before or during activation, a second container for receiving the plasma after activation, means for sterile transfer of plasma, means for contacting the plasma with the activator, and means for separating them.
Inventors:
Pata, Jean-Louis
Derma, Olivier
Schmidt Ausle, Laurent
Derma, Olivier
Schmidt Ausle, Laurent
Application Number:
JP52971998A
Publication Date:
September 02, 2004
Filing Date:
December 30, 1997
Export Citation:
Assignee:
Bio Holdings International Limited
International Classes:
A61L24/10; A61L24/00; (IPC1-7): A61L24/00
Domestic Patent References:
| JP7505076A | ||||
| JP7506349A | ||||
| JP57050923A |
Attorney, Agent or Firm:
Shigeru Yagida
Takao Hamano
Morita Tetsuji
Takao Hamano
Morita Tetsuji