Title:
組換えアワガエリ草花粉アレルゲンPh1 p ▲II▼
Document Type and Number:
Japanese Patent JP3657604
Kind Code:
B2
Abstract:
A recombinant DNA molecule codes for a peptide with the antigenicity of timothy grass pollen allergens Phl p II. The amino acid sequence (5) and the most important B cell and T cell epitopes of the molecule are derived therefrom. The recombinant Phl p II allergen is expressed in Escherichia coli and binds serum IgE of more than 60 % of all those allergic to grass pollen and may therefore be used in the same way as the naturally occurring Phl p II for processes based on antigen-antibody interaction, mediator release and T cell reactivity.
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Inventors:
Dressec christian
Furtara Suzanne
Rafel Silvia
Steinberger Peter
Craft dietrich
Shiner Otto
Valentor Rudolph
Furtara Suzanne
Rafel Silvia
Steinberger Peter
Craft dietrich
Shiner Otto
Valentor Rudolph
Application Number:
JP52145094A
Publication Date:
June 08, 2005
Filing Date:
March 31, 1994
Export Citation:
Assignee:
Biomei Products-Und Handels Geselschaft M. B. Her.
International Classes:
A61K39/36; A61P37/08; C07K14/00; C07K14/415; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N15/09; C12N5/10; C12N15/29; C12P21/02; G01N33/53; A61K38/00; C12N; (IPC1-7): C12N15/09; A61K39/36; A61P37/08; C07K14/00; C07K14/415; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Other References:
J Biol Chem, 1989, Vol.264, p.11181-11185
Int Arch Allergy Immunol, 1992, Vol.97, pp.287-294
FEBS, 1993, Vol.335, No.3, pp.299-304
Int Arch Allergy Immunol, 1992, Vol.97, pp.287-294
FEBS, 1993, Vol.335, No.3, pp.299-304
Attorney, Agent or Firm:
Nozomi Watanabe
Haruko Sanwa
Haruko Sanwa