Title:
(4-スルホニルアミノ)テトラヒドロピラン-4-カルボン酸ヒドロキサミド
Document Type and Number:
Japanese Patent JP3660873
Kind Code:
B2
Abstract:
PCT No. PCT/IB99/00505 Sec. 371 Date Sep. 1, 1999 Sec. 102(e) Date Sep. 1, 1999 PCT Filed Mar. 24, 1999 PCT Pub. No. WO99/52889 PCT Pub. Date Oct. 21, 1999A compound of the formula wherein Q is as defined above, are useful in the treatment of a condition selected from the group consisting of arthritis (including osteoarthritis and rheumatoid arthritis), inflammatory bowel disease, Crohn's disease, emphysema, chronic obstructive pulmonary disease, Alzheimer's disease, organ transplant toxicity, cachexia, allergic reactions, allergic contact hypersensitivity, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, osteoporosis, loosening of artificial joint implants, atherosclerosis (including atherosclerotic plaque rupture), aortic aneurysm (including abdominal aortic aneurysm and brain aortic aneurysm), congestive heart failure, myocardial infarction, stroke, cerebral ischemia, head trauma, spinal cord injury, neuro-degenerative disorders (acute and chronic), autoimmune disorders, Huntington's disease, Parkinson's disease, migraine, depression, peripheral neuropathy, pain, cerebral amyloid angiopathy, nootropic or cognition enhancement, amyotrophic lateral sclerosis, multiple sclerosis, ocular angiogenesis, corneal injury, macular degeneration, abnormal wound healing, burns, diabetes, tumor invasion, tumor growth, tumor metastasis, corneal scarring, scleritis, AIDS, sepsis and septic shock. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.
Inventors:
Writer, Lawrence Alan
Application Number:
JP2000543449A
Publication Date:
June 15, 2005
Filing Date:
March 24, 1999
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
A61K31/351; A61P1/00; A61P1/02; A61P1/04; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P17/02; A61P19/02; A61P19/10; A61P25/00; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P35/04; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07D309/08; C07D309/14; C07D405/12; (IPC1-7): C07D309/14; C07D405/12
Domestic Patent References:
| JP2001122775A | ||||
| JP11263735A | ||||
| JP11199512A |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto