Title:
皮下グルコース電極
Document Type and Number:
Japanese Patent JP3679121
Kind Code:
B2
Abstract:
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
Inventors:
Heller, Adam
Pischko, Michael Vui
Pischko, Michael Vui
Application Number:
JP50898196A
Publication Date:
August 03, 2005
Filing Date:
September 01, 1995
Export Citation:
Assignee:
Heller, Adam
Pischko, Michael Vui
Pischko, Michael Vui
International Classes:
G01N27/327; A61B5/145; A61B5/1473; A61B5/1486; A61B5/1495; C12M1/40; C12Q1/00; C12Q1/54; (IPC1-7): A61B5/145; C12M1/40; C12Q1/54; G01N27/327
Domestic Patent References:
| JP62123349A |
Foreign References:
| WO1992013271A1 |
Attorney, Agent or Firm:
Yoichiro Shimoda