Title:
医薬製剤におけるカルシウム活性化中性プロテアーゼ抑制因子の使用
Document Type and Number:
Japanese Patent JP3703828
Kind Code:
B2
Abstract:
The invention relates to the use of inhibitors of neutral Ca<2+> dependent proteinases (CANPs) and their pharmaceutically acceptable addition salts or their active subunits in the field of tumour therapy, especially cancer therapy, viral diseases therapy, AIDS therapy and contraception. The inhibitors can especially be used against protease bound glycosaminoglycan-substrate dependent tumours, viral diseases and contraception by selective malignant cell killing, viruses and spermatozoa killing and inhibiting of nuclear vlimmata in a host-parasite cell system involving common protease bound substrate. The inhibitors are heatstable, tetrameric proteins at neutral pH, approximatively 240 KDa, destroyed with trypsin. The pharmaceutical compositions may be prepared in a manner known per se, with carriers or additives commonly used in the pharmaceutical industry.
Inventors:
Logo seturera, helen
Application Number:
JP51122392A
Publication Date:
October 05, 2005
Filing Date:
June 02, 1992
Export Citation:
Assignee:
NORSK HYDRO ASA
International Classes:
A61K38/55; A61P31/12; A61P31/18; A61P35/00; C07K14/81; (IPC1-7): A61K38/55; A61P35/00
Attorney, Agent or Firm:
Michiteru Soga
Yutaka Ikeya
Hidetoshi Furukawa
Suzuki Kenchi
Masahisa Hase
Yutaka Ikeya
Hidetoshi Furukawa
Suzuki Kenchi
Masahisa Hase