Title:
4-フルオロ-2-シアノピロリジン誘導体ベンゼンスルホン酸塩
Document Type and Number:
Japanese Patent JP3746063
Kind Code:
B2
Abstract:
A benzenesulfonate salt of (2S,4S)-2-cyano-4-fluoro-1-Ä(2-hydroxy-1,1-dimethyl)ethylaminoÜacetylpyrrolidine that has an excellent DPPIV inhibition activity as well as physical properties (e.g., stability) required for pharmaceutical preparations. The present invention allows easy obtaining of the compound in high-purity uniform crystal form with excellent solid-state stability.
Inventors:
Hiroshi Fukushima
Akira Hiradate
Masato Takahashi
Kazuya Kameo
Akira Hiradate
Masato Takahashi
Kazuya Kameo
Application Number:
JP2004532725A
Publication Date:
February 15, 2006
Filing Date:
August 27, 2003
Export Citation:
Assignee:
Taisho Pharmaceutical Co., Ltd.
International Classes:
C07D207/16; A61K31/40; A61P3/04; A61P3/10; A61P13/08; A61P19/02; A61P19/10; A61P37/00; A61P43/00
Domestic Patent References:
| JP2000198784A | ||||
| JP2002531459A | ||||
| JP62240660A | ||||
| JP58201792A |
Foreign References:
| WO2002038541A1 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi