Title:
結合組織細胞に部分的又は完全に分化した骨髄幹細胞の有効培養物及びヒアルロン酸誘導体より成る三次元の生体親和性で且つ生分解性のマトリックスから構成される生物学的物質
Document Type and Number:
Japanese Patent JP3808900
Kind Code:
B2
Abstract:
A biological material comprising two components is provided containing a first component comprising alternatively (1) a culture of autologous or homologous bone marrow stem cells partially or completely differentiated into specific connective tissue cellular lines or (2) a sole extracellular matrix free from any cellular component secreted by the specific connective tissue cellular lines; and a second component containing a three-dimensional biocompatible and biodegradable matrix consisting of a hyaluronic acid ester having a degree of esterification comprised between 25 and 100%. The specific tissue cell lines are selected from fibroblasts, osteoblasts, myoblasts, adipocytes, chondrocytes and endothelial cells. The biological material is suitable for use as a dermal substitute in cutaneous lesions as well as repairing damaged connective tissue.
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Inventors:
Abatangelo Giovanni
Carregalo Lanfranco
Carregalo Lanfranco
Application Number:
JP51938597A
Publication Date:
August 16, 2006
Filing Date:
November 19, 1996
Export Citation:
Assignee:
Fidia Advanced Biopolymers Societa A Responsor Billita Limitata
International Classes:
A61L27/00; A61L15/28; A61L27/20; A61L27/38; A61L27/60; C12N5/00; C12N5/071; C12N5/077; A61K35/12
Domestic Patent References:
| JP4505717A | ||||
| JP4501657A | ||||
| JP1501362A | ||||
| JP7194373A | ||||
| JP4231061A | ||||
| JP7502430A | ||||
| JP7023779A | ||||
| JP2500800A | ||||
| JP11507558A |
Foreign References:
| US5197985 | ||||
| WO1994017837A1 | ||||
| US5541106 |
Other References:
Cortivo, R, In vitro studies on biocompatibility of hyaluronic acid esters, Biomaterials, 1991年,12, pp.727-730
Attorney, Agent or Firm:
Jyohei Yamashita