Title:
3,3-ジフェニル-2,3-エポキシプロピオン酸エステルのエナンチオ選択的製造方法
Document Type and Number:
Japanese Patent JP3817478
Kind Code:
B2
Abstract:
The invention relates to a process for the enantioselective preparation of glycide ester (I) by(a) dihydroxylation of a corresponding 3-phenyl cinnamate (II) by osmium (VIII) oxide catalysis in the presence of a Sharpless ligand and an oxidizing agent to form the dihydroxy ester (III),(b) selective conversion of the hydroxy function in position 2 of the dihydroxy ester (III) to a leaving group,(c) intramolecular substitution of the leaving group through the hydroxy function in position 3 to form the glycide ester (I),in whichR1 denotes C1-C10 alkyl, aryl, or arylalkyl, which may be substituted,R2 denotes C1-C10 alkyl, aryl, arylalkyl, halogen, C1-C10 alkoxy, acyloxy, or amide, which may be substituted, andn is 0 to 5.
Inventors:
Rolf Janssen
Application Number:
JP2001553756A
Publication Date:
September 06, 2006
Filing Date:
January 12, 2001
Export Citation:
Assignee:
Abbott GmbH & Co. KG
International Classes:
C07D301/03; C07B61/00; C07C69/732; C07D303/48
Domestic Patent References:
| JP10507190A |
Other References:
J. Org. Chem.,1990, Vol.55, No.6,pp.1957-1959
Indian Journal of Chemistry,1992, Vol.31B, No.10,pp.641-644
Indian Journal of Chemistry,1992, Vol.31B, No.10,pp.641-644
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard