Title:
グルタミン酸塩およびNMDAレセプターにおけるペプチド拮抗物質の使用方法
Document Type and Number:
Japanese Patent JP3819932
Kind Code:
B2
Abstract:
The invention relates to the use of a new type of peptide antagonists at glutamate receptors and a subtype of glutamate receptors (NMDA (N-methyl-D-aspartate)) for the manufacture of a medicament to influence the glutamate receptor and the NMDA-receptor controlled cells such as neurons or glial cells in the central nervous system.
Inventors:
Bouguinon Jay Pee
Application Number:
JP52470594A
Publication Date:
September 13, 2006
Filing Date:
May 16, 1994
Export Citation:
Assignee:
Neurons Limited
International Classes:
A61K38/00; A61K38/06; A61K38/09; A61K38/25; A61K38/28; A61K38/30; A61P3/08; A61P9/10; A61P25/00; A61P43/00
Other References:
SARA V.R. et al., Identification of Gly-Pro-Glu(GPE), The aminoterminal tripeptide of Insulin-Like Growth Factor 1 whi, Biochemical and Biophysical Research Communications, 1989年,Vol.165, No.2, p.766-771
BOURGUIGNON JP. et al., Direct Activation of Gonadotropin-Releasing Hormone Secretion Through Different Receptors to Neuroex, Neuroendocrinology, 1989年,Vol.49, p.402-408
BOURGUIGNON JP. et al., Pulsatile Release of Gonadotropin-Releasing Hormone from Hypothalamic Explamts is Restrained by Bloc, Endocrinology , 1989年,Vol.125, No.2, p.1090-1096
BOURGUIGNON JP. et al., Neuroendocrine Mechanism of Onset og Puberty,;Sequential Reduction in Activity of Inhibitory and Fac, The Journal of Clinical Investigation, 1992年,Vol.90, p.1736-1744
SIMON R.P. et al., Blockade of N-Methyl-D-Aspartate Receptors may Protect Against Ischemic Damage in the Brain, Science, 1984年,Vol.226, No.4676, p.850-852
WIELOCH T., Hypoglycemia-Induced Neuronal Damage Prevented by an N-Methyl-D-Aspartate Antagonist, Science, 1985年,Vol.230, No.4726, p.681-683
McDonald J.W. et al., Physiological and pathophysiological roles of excitatory amino acids during central nervous system d, Brain Research Reviews, 1990年,Vol.15, p.41-70
CHOI D.W., Glutamate Neurotoxicity and Disease of the Nervous System,Neuron, 1988年,Vol.1, p.623-634
BOURGUIGNON JP. et al., Direct Activation of Gonadotropin-Releasing Hormone Secretion Through Different Receptors to Neuroex, Neuroendocrinology, 1989年,Vol.49, p.402-408
BOURGUIGNON JP. et al., Pulsatile Release of Gonadotropin-Releasing Hormone from Hypothalamic Explamts is Restrained by Bloc, Endocrinology , 1989年,Vol.125, No.2, p.1090-1096
BOURGUIGNON JP. et al., Neuroendocrine Mechanism of Onset og Puberty,;Sequential Reduction in Activity of Inhibitory and Fac, The Journal of Clinical Investigation, 1992年,Vol.90, p.1736-1744
SIMON R.P. et al., Blockade of N-Methyl-D-Aspartate Receptors may Protect Against Ischemic Damage in the Brain, Science, 1984年,Vol.226, No.4676, p.850-852
WIELOCH T., Hypoglycemia-Induced Neuronal Damage Prevented by an N-Methyl-D-Aspartate Antagonist, Science, 1985年,Vol.230, No.4726, p.681-683
McDonald J.W. et al., Physiological and pathophysiological roles of excitatory amino acids during central nervous system d, Brain Research Reviews, 1990年,Vol.15, p.41-70
CHOI D.W., Glutamate Neurotoxicity and Disease of the Nervous System,Neuron, 1988年,Vol.1, p.623-634
Attorney, Agent or Firm:
Hideo Dobashi
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