Title:
QS-21を伴う、ガングリオシド‐KLH複合体
Document Type and Number:
Japanese Patent JP3852945
Kind Code:
B2
Abstract:
This invention provides a vaccine for stimulating or enhancing the production of an antibody which recognizes a ganglioside in a subject to which the vaccine is administered. The vaccine is comprised of an amount of ganglioside or oligosaccharide portion thereof conjugated to an immunogenic protein effective to stimulate or enhance antibody production in the subject. The vaccine is further comprised of an adjuvant and a pharmaceutically acceptable vehicle. The invention also provides a method of using the vaccine for treating or preventing cancer wherein gangliosides are on the surface or in the stroma of the cancer cells.This invention provides a vaccine for stimulating or enhancing the production of an antibody which recognizes a ganglioside in a subject to which the vaccine is administered. The vaccine is comprised of an amount of ganglioside or oligosaccharide portion thereof conjugated to an immunogenic protein effective to stimulate or enhance antibody production in the subject. The vaccine is further comprised of an adjuvant and a pharmaceutically acceptable vehicle. The invention also provides a method of using the vaccine for treating or preventing cancer wherein gangliosides are on the surface or in the stroma of the cancer cells.
Inventors:
Livingston, Philip O
Herring, Fried Helm
Herring, Fried Helm
Application Number:
JP51720394A
Publication Date:
December 06, 2006
Filing Date:
January 21, 1994
Export Citation:
Assignee:
Sloan-Kettering Institute for Cancer Research
International Classes:
A61K39/00; A61K45/00; A61K31/70; A61K45/08; A61K47/48; A61P35/00
Domestic Patent References:
| JP2184700A |
Foreign References:
| US5102663 |
Other References:
Sem. in Cancer Biol., 1991, Vol.2, No.6, pp.401-409
J. Immunol., 1991, Vol.146, No.2, pp.431-437
J. Immunol., 1991, Vol.146, No.2, pp.431-437
Attorney, Agent or Firm:
Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto
Hanawa Yoshio
Sadao Muramatsu
Ryo Hashimoto
Hanawa Yoshio