ビスホスホン酸作製のための特定の希釈剤の使用

Title:

ビスホスホン酸作製のための特定の希釈剤の使用

Document Type and Number:

Japanese Patent JP3857706

Kind Code:

B2

Abstract:

Provided is a novel method of making bisphosphonic acids, e.g. risedronic acid, including the step of combining a carboxylic acid, phosphorous acid, and a halophosphorous compound in the presence of a diluent that is an aromatic hydrocarbon or a silicone fluid. When the diluent is an aromatic hydrocarbon, an inert support or ortho-phosphoric acid codiluent is advantageously included.

Inventors:

Riddle-Hadas, Rami
Harrel, Zubi
Rifushitsu-Liron, Revital
Kovalevski-Shy, Eti

Application Number:

JP2004505386A

Publication Date:

December 13, 2006

Filing Date:

May 19, 2003

Export Citation:

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