Title:
グルコキナーゼ活性化物質
Document Type and Number:
Japanese Patent JP3884232
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula (I) wherein R<1>, R<2>, R<3> and R<4> are as defined in claim 1 and pharmaceutically acceptable salts thereof. The compounds are glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
Inventors:
Bisaro, fred thomas
Corbett, Wendy Lee
Fossera, Antonino
Grippo, Joseph Francis
Haines, Nancy-Ellen
Holland, George William
Kester, Robert Francis
Mahony, Page Yi
Sarah, Ramakans
Corbett, Wendy Lee
Fossera, Antonino
Grippo, Joseph Francis
Haines, Nancy-Ellen
Holland, George William
Kester, Robert Francis
Mahony, Page Yi
Sarah, Ramakans
Application Number:
JP2000607996A
Publication Date:
February 21, 2007
Filing Date:
March 20, 2000
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D277/20; A61K31/17; A61K31/4168; A61K31/42; A61K31/421; A61K31/426; A61K31/433; A61K31/4402; A61K31/455; A61K31/50; A61K31/505; A61P3/10; A61P43/00; C07C275/50; C07C317/44; C07C323/60; C07C323/62; C07D213/75; C07D213/80; C07D213/803; C07D213/82; C07D233/88; C07D237/20; C07D237/22; C07D239/42; C07D241/28; C07D253/07; C07D261/14; C07D263/34; C07D263/48; C07D277/38; C07D277/46; C07D277/56; C07D277/58; C07D285/135; C07D285/12; C07D
Foreign References:
| US3776917 | ||||
| GB969022A | ||||
| WO1998027063A1 |
Other References:
M.A.Spielman et al.,Anticonvulsant Drugs. II. Some Acylureas,Journal of the American Chemical Society,1948年,Vol.70, No.12,p.4189-4191
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda