Title:
5-HT2レセプター親和性を有する置換四環状オキサゼピン及びチアゼピン誘導体
Document Type and Number:
Japanese Patent JP3887785
Kind Code:
B2
Abstract:
PCT No. PCT/EP95/04197 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Oct. 25, 1995 PCT Pub. No. WO96/14321 PCT Pub. Date May 17, 1996This invention concerns the compounds of formula (I), the pharmaceutically acceptable salts and stereoisomeric forms thereof, and also the N-oxide forms thereof. (I) wherein: R1 and R2 each independently are hydrogen; C1-6alkyl; C1-6alkylcarbonyl; trihalomethylcarbonyl; C1-6alkyl substituted with hydroxy, C1-6alkyloxy, carboxyl, C1-6alkylcarbonyloxy, C1-6alkyloxycarbonyl or aryl; or R1 and R2 taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle; R3 to R10 each independently are hydrogen, halo, cyano, hydroxy, trifluoromethyl, trifluoromethoxy, carboxyl, nitro, amino, mono- or di(C1-6alkyl)amino, C1-6alkylcarbonylamino, aminosulfonyl, mono- or di(C1-6alkyl)-aminosulfonyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl; R11 is hydrogen, C1-6alkyl, or trifluoromethyl; R12 is hydrogen, C1-6alkyl, cyano, or trifluoromethyl; n is zero to 6; and X is O, S, S(=O) or S(=O)2. The compounds of formula (I) may be used as therapeutic agents in the treatment or the prevention of CNS disorders, cardiovascular disorders or gastrointestinal disorders.
Inventors:
Fernandez-Gadea, Francisco Javier
Shipid, Victor Karel
Andres-Jill, Jose Ignacio
Mailt, Theo Franc
Shipid, Victor Karel
Andres-Jill, Jose Ignacio
Mailt, Theo Franc
Application Number:
JP51501096A
Publication Date:
February 28, 2007
Filing Date:
October 25, 1995
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D498/04; A61K31/535; A61K31/55; A61K31/553; A61K31/554; A61P9/00; A61P25/00; A61P25/18; A61P25/24; A61P25/26; C07D261/20; C07D267/16; C07D513/04; A61P1/04; A61P3/04; A61P25/06; A61P25/08; A61P25/20; A61P25/22; A61P25/28; A61P25/30; A61P43/00
Domestic Patent References:
| JP46004172B1 |
Foreign References:
| WO1996033983A1 | ||||
| US4039558 | ||||
| GB1227190B | ||||
| US3652550 |
Other References:
MOFFETT, Robert Bruce, ”Tetracyclic heterocycles as central nervous system (CNS) agents”, Journal of Heterocyclic Chemistry, 1980年 3月,Vol.17, No.2, p.341-50
Attorney, Agent or Firm:
Heikichi Odashima
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