Title:
N-置換ヒドロキシピリミジノンカルボキサミド系HIVインテグラーゼ阻害薬
Document Type and Number:
Japanese Patent JP3927175
Kind Code:
B2
Abstract:
N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R1, R2, R3 and R4 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
Inventors:
Crescientui, Benedetta
Gardeturi, Christina
Muglia, ester
Nitsui, Emanuela
Orvieto, Huederika
Pachie, paola
Pescatore, Giovanna
Petrotsuki, Alessia
Poma, Marco
Raleigh, Michael
Skull Petsuri, Rita
Summa, Vincenttsuo
Gardeturi, Christina
Muglia, ester
Nitsui, Emanuela
Orvieto, Huederika
Pachie, paola
Pescatore, Giovanna
Petrotsuki, Alessia
Poma, Marco
Raleigh, Michael
Skull Petsuri, Rita
Summa, Vincenttsuo
Application Number:
JP2003537644A
Publication Date:
June 06, 2007
Filing Date:
October 21, 2002
Export Citation:
Assignee:
ESTACH YOUT DAY LICHIERQUE DAY VIOLOSIA MORE CORRALE PI ANGE ELETS ESET PEAR
International Classes:
C07D239/46; C07D239/54; A61K31/513; A61K31/515; A61K31/5377; A61K39/00; A61P31/18; A61P43/00; C07D239/557; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/10; C07D403/12; C07D403/14; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D513/04; A61K; C07D
Domestic Patent References:
| JP2002538144A | ||||
| JP2004504304A |
Foreign References:
| WO2003016275A1 | ||||
| WO2001085700A1 |
Other References:
Inorg. Chem., 2001, Vol.40, No.26, pp.6746-6756
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura