Title:
インスリン抵抗性および糖尿病のための、コリン塩基とコハク酸とを含む相乗効果のある組成物
Document Type and Number:
Japanese Patent JP3944393
Kind Code:
B2
Abstract:
This invention relates to compositions and methods for achieving a synergistic effect in treating insulin resistance and diabetes mellitus in a mammal. More specifically, this invention relates to synergistic composition comprising amounts of choline base or a pharmaceutically acceptable salt thereof and succinic acid or a pharmaceutically acceptable salt thereof, which are presented in amounts sufficient to cause synergistic effects in treating insulin resistance and diabetes mellitus in a mammal. Further, this invention relates to methods for achieving a synergistic effects in treating insulin resistance and diabetes mellitus in a mammal, which methods comprise administering to said mammal, either stepwise or simultaneously, effective amounts of choline base or a pharmaceutically acceptable salt thereof and succinic acid or a pharmaceutically acceptable salt thereof. Further, this invention relates to a novel derivative of choline. More specifically, this invention relates to bis(2-hydroxy-N,N,N-trimethylethanaminium) succinate, the novel salt of choline formed by choline base and succinic acid in the molar ratio 2:1, a process for producing the salt, and use of the salt in medicine, preferably for the manufacture of a medicament for treating insulin resistance, hyperlipidemia, dyslipidemia, or diabetes mellitus.
Inventors:
Igor Anatolyevich Pomitkin
Olga Evgenievna Korsova
Tatiana Yuryevna Ukhhanova
Olga Evgenievna Korsova
Tatiana Yuryevna Ukhhanova
Application Number:
JP2001574101A
Publication Date:
July 11, 2007
Filing Date:
April 10, 2000
Export Citation:
Assignee:
Pavel Vaslievich Vertelesky
Igor Anatolyevich Pomitkin
Igor Anatolyevich Pomitkin
International Classes:
A61K31/14; A61P3/06; A61K31/19; A61K31/194; A61K31/221; A61P3/10
Domestic Patent References:
| JP3169498A | ||||
| JP61171417A |
Foreign References:
| US5895652 | ||||
| US5124061 | ||||
| EP0652012A1 |
Other References:
Camu, F.,Archives Internationales de Pharmacodynamie et de Therapie,1973年,Vol.201, No.1,pp.189-190
Nogami, H. et al.,Chemical & pharmaceutical bulletin ,1961年,Vol.9, No.8,pp.646-650
Nogami, H. et al.,Chemical & pharmaceutical bulletin ,1961年,Vol.9, No.8,pp.646-650
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto