Title:
組換えヒト副甲状腺ホルモンを生産する形質転換酵母及び該ホルモンの生産方法
Document Type and Number:
Japanese Patent JP3957630
Kind Code:
B2
Abstract:
Novel Saccharomyces Cerevisiae mutant strains are provided for producing human parathyroid hormone. The novel strains acre genetically disrupted in at least one of the genes encoding the yapsin family of proteases Yapsin 1, Yapsin 2 and Yapsin 3 and harbor a human parathyroid hormone gene in their genomes. Culturing the novel strains results in the secretion of intact hPTH into culture media at high yield.
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Inventors:
Lee, Sun, Ki
Cana, Hyun, Ah
Chang, Bonn, Hyun
Ko, Su, Min
Cana, Hyun, Ah
Chang, Bonn, Hyun
Ko, Su, Min
Application Number:
JP2002524073A
Publication Date:
August 15, 2007
Filing Date:
August 27, 2001
Export Citation:
Assignee:
Don Cook Pharmaceutical Company Limited
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
International Classes:
C12N15/09; C07K14/635; C12N1/18; C12N1/19; C12N9/60; C12N15/16; C12P21/00; C12P21/02
Foreign References:
| WO1999037758A1 |
Other References:
Appl.Microbiol.Biotechnol.,1998年,50(2),187-192
Process Biochemistry,2000年 1月,35,503-508
Process Biochemistry,2000年 1月,35,503-508
Attorney, Agent or Firm:
Shintaro Nogawa