Title:
機能性分子及びその製造方法
Document Type and Number:
Japanese Patent JP3978187
Kind Code:
B2
Abstract:
The object of the present invention is to provide a process for producing a functional molecule having a high affinity to various targets. Accordingly, the process for producing the functional molecule includes a producing step which produces a modified oligonucleotide sequence by polymerizing randomly a modified nucleotide n-mer (where, n represents an integer) containing a modified nucleoside prepared by introducing a substituent into a nucleoside composing a nucleic acid. An aspect preferably comprises a selecting step which selects a sequence having an affinity to a target from the modified oligonucleotide sequence, a determining step which amplifies the selected modified oligonucleotide sequence and determines the base sequence thereof, and a translating step which translates the sequence of the modified oligonucleotide sequence, of which base sequence has been determined, on the basis of a relation table prepared by relating at least one of 4 kinds of nucleotide n-mers, which are presented in the relation table prepared by the one-to-one combination of 4 kinds of nucleosides, to a modified nucleotide n-mer.
Inventors:
Takeshi Fujiwara
Shozo Fujita
Shunsaku Takeishi
Shozo Fujita
Shunsaku Takeishi
Application Number:
JP2003576617A
Publication Date:
September 19, 2007
Filing Date:
March 14, 2003
Export Citation:
Assignee:
富士通株式会社
International Classes:
C12N15/09; A61K31/7115; A61P3/00; A61P7/04; A61P21/04; A61P25/14; A61P35/00; C07H21/00; C07H21/04; C12N15/10; C12N15/115; C12P19/34; C12Q1/68; A61K48/00
Domestic Patent References:
| JP6503809A | ||||
| JP2001521040A |
Other References:
Nucleic Acids Res., vol.24(17), pp.3407-3414 (1996)
Attorney, Agent or Firm:
Koichi Hirota