Title:
FAS受容体およびほかのタンパク質の機能のモジュレーター
Document Type and Number:
Japanese Patent JP3980641
Kind Code:
B2
Abstract:
The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors which interfere with the proteolytic activity of MORT-1-binding proteins having proteolytic activity are provided as well as a method of designing them.
Inventors:
Wallac, David
Boldin, Mark
Goncharov, Tanya
Goldsev, Yury Buoy
Boldin, Mark
Goncharov, Tanya
Goldsev, Yury Buoy
Application Number:
JP50667597A
Publication Date:
September 26, 2007
Filing Date:
June 14, 1996
Export Citation:
Assignee:
Yeda Research and Development Company Limited
International Classes:
C12N15/09; A61K45/00; A61K48/00; A61P31/12; A61P35/00; C07K14/47; C07K14/705; C07K14/715; C07K16/28; C12N1/21; C12N5/10; C12N9/64; C12P21/02; A61K38/00
Other References:
J. Biol. Chem., 1995年 4月, vol.270, p.7795-7798
Attorney, Agent or Firm:
Sota Asahina
Kei Saki
Kei Saki