Title:
シアノピロリジン誘導体
Document Type and Number:
Japanese Patent JP3987890
Kind Code:
B2
Abstract:
A cyanopyrrolidine derivative represented by Formula (1):
[wherein R 1 is a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, R 2 is a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, or R 1 and R 2 together form an oxo, a hydroxyimino group, an alkoxyimino group having 1 to 5 carbon atoms or an alkylidene group having 1 to 5 carbon atoms,
R 3 and R 4 are each a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, or R 3 and R 4 together form an oxo, a hydroxyimino group, an alkoxyimino group having 1 to 5 carbon.atoms or an alkylidene group having 1 to 5 carbon atoms,
X is an oxygen atom or a sulfur atom,
Y is -CR 5 R 6 - (wherein R 5 and R 6 are the same or different, and are each a hydrogen atom, a halogen atom, an optionally substituted alkyl group having 1 to 10 carbon atoms or an optionally substituted alkenyl group having 2 to 10 carbon atoms),
or -CR 7 R 8 -CR 9 R 10 - (wherein R 7 , R 8 , R 9 and R 10 are the same or different, and each a hydrogen atom, a halogen atom or an optionally substituted alkyl group having 1 to 10 carbon atoms, or R 7 and R 9 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl group having 3 to 8 carbon atoms, an optionally substituted cycloalkenyl group having 4 to 8 carbon atoms, an optionally substituted bicycloalkyl group having 5 to 10 carbon atoms, or an optionally substituted bicycloalkenyl group having 5 to 10 carbon atoms) and
Z is a hydrogen atom or an optionally substituted alkyl group having 1 to 10 carbon atoms, or Y and Z together with the nitrogen atom to which they are attached form an optionally substituted cyclic amino group having 2 to 10 carbon atoms], or a pharmaceutically acceptable salt thereof.
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Inventors:
Hiroshi Fukushima
Akira Hiradate
Masato Takahashi
Kazuya Kameo
Akira Hiradate
Masato Takahashi
Kazuya Kameo
Application Number:
JP2002541077A
Publication Date:
October 10, 2007
Filing Date:
November 09, 2001
Export Citation:
Assignee:
Taisho Pharmaceutical Co., Ltd.
International Classes:
C07D207/16; A61P3/10; A61P29/00; A61P31/18; A61P35/04; A61P37/02; A61P43/00; C07D207/24; C07D401/06; C07D401/12
Foreign References:
| WO2000056296A1 | ||||
| WO2000056297A1 | ||||
| WO1998019998A1 | ||||
| US6011155 | ||||
| WO2000034241A1 | ||||
| WO2001034594A1 | ||||
| WO2001081337A1 | ||||
| WO2002014271A1 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Yamaguchi