Title:
メラニンの製造
Document Type and Number:
Japanese Patent JP4021485
Kind Code:
B2
Abstract:
A method of producing a melanin comprises oxidizing a phenolic compound at one or more hydroxyl groups thereof, wherein the phenolic compound is selected from 5-hydroxyindole and derivatives thereof and compounds of formula (1) and the oxidation is provided by biotransformation in the presence of an oxidoreductase enzyme, the compound of formula (1),wherein R1 is H or OH; R2 is H, OH orOCH3; R3 is H or OH at least one of R1 and R3 being OH; R4 is selected from H , R, -COOX and R7-COOX, wherein R is an optionally substituted saturated or unsaturated alkyl group having from 1 to 12 carbon atoms, R7 is an optionally substituted saturated or unsaturated alkylene group having from 1 to 12 carbon atoms and X is selected from H and aliphatic and aromatic ester forming groups; and R5 and R6 is each independently selected from H, OH, NH2, OCH3, CH3, SH, NHCO2, NHCH3, COOH and saturated or unsaturated alkyl groups having up to 8 carbon atoms.
Inventors:
Nigel Eric Bannister
Cheetham, Peter Samuel James
Cheetham, Peter Samuel James
Application Number:
JP52109297A
Publication Date:
December 12, 2007
Filing Date:
December 09, 1996
Export Citation:
Assignee:
Zyrepsis Limited
International Classes:
C12P17/18; A61K8/30; A61K8/33; A61K8/368; A61K8/41; A61K8/46; A61K8/66; A61P17/16; C09B69/10; C12P17/00
Domestic Patent References:
| JP6090776A | ||||
| JP6500011A | ||||
| JP6505960A |
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Takashi Watanabe