非耐熱性エンテロトキシンとコレラトキシンBサブユニットの雑種分子

Japanese Patent JP4081140

B2

PCT No. PCT/SE96/00570 Sec. 371 Date Jan. 5, 1998 Sec. 102(e) Date Jan. 5, 1998 PCT Filed May 2, 1996 PCT Pub. No. WO96/34893 PCT Pub. Date Nov. 7, 1996Hybrid molecules between heat-labile enterotoxin B subunit (LTB) and cholera toxin B subunit (CTB) are disclosed. Such a hybrid molecule comprises an amino-acid sequence which is composed of the amino-acid sequence of mature CTB in which such amino-acid residues are substituted with the corresponding amino-acid residues of mature LTB which impart LTB-specific epitope characteristics to said immunogenic mature CTB, or vice versa. In addition, a structural gene coding for such a hybrid molecule, a plasmid containing such a structural gene, and an immunogenic protein comprising such a hybrid molecule and optionally an immunoreactive amino-acid sequence of a prokaryotic or eukaryotic cell or a virus, are disclosed. Disclosed is also a vaccine, e.g. against enterotoxin-induced illness, comprising such an immunogenic protein, and a method of preventing or treating enterotoxin-induced illness in an individual.

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Holm Glen, Yang
Levens, Michael Earl

JP53323796A

April 23, 2008

May 02, 1996

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Holm Glen, Yang
Levens, Michael Earl

C12N15/09; A61K39/00; A61K39/106; A61K39/108; A61P31/04; A61P31/12; C07K14/24; C07K14/245; C07K14/28; C07K19/00; C12P21/02

Gene,1994,149(2),p.211-7
Infect.Immun.,1996 Jun,64(6),p.2144-50

Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Hiroyuki Tomita

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