抗虚血性ヒドロキシルアミン誘導体および医薬組成物

Title:

抗虚血性ヒドロキシルアミン誘導体および医薬組成物

Document Type and Number:

Japanese Patent JP4083800

Kind Code:

B2

Abstract:

PCT No. PCT/HU96/00033 Sec. 371 Date May 13, 1998 Sec. 102(e) Date May 13, 1998 PCT Filed Jun. 14, 1996 PCT Pub. No. WO97/00251 PCT Pub. Date Jan. 3, 1997The present invention provides novel hydroxylamine derivatives represented by the general formula: wherein: X is O, -NH, or a group of formula NR', wherein R and R' are independently selected from alkyl, cycloalkyl, phenylalkyl, phenyl optionally substituted with halo, haloalkyl, alkyl, alkoxy or nitro; and a N-containing heterocyclic ring; R1 is H or alkanoyl, R2 is H or hydroxy optionally acylated with alkanoyl, and R3 is a group of the formula -NR4R5 wherein R4 and R5 are independently selected from H, alkyl, and a group of the formula -CO-NH-R wherein R is as defined above, or wherein R4 and R5 when taken together form a 5- to 7-membered heterocyclic ring which may optionally contain one additional hetero atom selected from nitrogen, oxygen and sulfur and which is optionally substituted with alkyl or phenylalkyl. Also provided are pharmaceutically acceptable acid addition salts of the compounds defined above, as well as pharmaceutical compositions containing the compounds or their acid addition salts as active ingredients. The compounds of the invention have been shown to have anti-ischemic effects.

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Inventors:

Eurogi, Larslaw
Mare Bagno, Ed
Barabash, Mihari
Yasuritsu, Larslaw
Below, Catalin
Edner kobitz, andrea
Radvanine Heggedus, Erjebeto
Curcy, maria
Udobaldi, Nadji, It's Bunny

Application Number:

JP50282997A

Publication Date:

April 30, 2008

Filing Date:

June 14, 1996

Export Citation:

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Assignee:

Biorex Kuta To S Fayrestee Arte.

International Classes:

A61K31/17; C07C275/64; A61K31/27; C07D295/08; A61K31/445; A61K31/495; A61K31/535; A61K31/5375; A61P9/08; A61P9/10; C07D213/75; C07D295/088; C07D295/092

Other References:

ハンガリー特許出願公開第66350号明細書

Attorney, Agent or Firm:

Takashi Ishida
Yoshio Yoshio
Toshio Toda
Masaya Nishiyama

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