Title:
βシート模倣物およびプロテアーゼインヒビターとしてのその使用
Document Type and Number:
Japanese Patent JP4152900
Kind Code:
B2
Abstract:
There are disclosed beta -sheet mimetics and methods relating to the same for imparting or stabilizing the beta -sheet structure of a peptide, protein or molecule. In one aspect, the beta -sheet mimetics are covalently attached at the end or within the length of the peptide or protein. The beta -sheet mimetics have utility as inhibitors of one or more of proteases, kinases, CAAX, peptides binding to SH2 domains and MHC-I and/or MHC-II presentation of peptides to T cell receptors in warm-blooded animals.
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Inventors:
Michael khan
Application Number:
JP2004017703A
Publication Date:
September 17, 2008
Filing Date:
January 26, 2004
Export Citation:
Assignee:
Molecularistics Limited
International Classes:
A61K31/437; A61K31/5025; A61K38/55; A61K38/00; A61P7/02; A61P9/10; A61P37/06; A61P43/00; C07C311/64; C07D471/04; C07D487/04; C07K5/02; C07K5/04; C07K5/06; C07K5/062; C07K5/08; C07K5/083; C07K5/10; C07K5/103; C07K7/06; C12N9/99
Domestic Patent References:
| JP8502746A |
Other References:
Jack E et al.,SYNTHESIS OF A BICYCLIC γ-LACTAM DIPEPTIDE ANALOGUE,Heterocycles,1992年,Vol.34, No.5,pp.903-906
Lino Colombo et al.,Conformationally Constrained Dipeptides: Synthesis of 7,5- and 6,5-Fused Bicyclic Lactams by Stereoselective Radical Cyclizations,Tetrahedron Letters,1995年,Vol.36, No.4,pp.625-628
Lino Colombo et al.,Conformationally Constrained Dipeptides: Synthesis of 7,5- and 6,5-Fused Bicyclic Lactams by Stereoselective Radical Cyclizations,Tetrahedron Letters,1995年,Vol.36, No.4,pp.625-628
Attorney, Agent or Firm:
Hidesaku Yamamoto