Title:
プロテインキナーゼインヒビターとして有用なピラゾール化合物
Document Type and Number:
Japanese Patent JP4160392
Kind Code:
B2
Abstract:
This invention describes novel pyrazole compounds of formula (I), wherein R 1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; R x , R y , R 2 , and R 2' are as described in the specification, and processes for preparing these compounds. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
Inventors:
David David
Charlie, Jean-Damien
Robert Davids
Golek, Julian
Kay, david
Ronald Negtel
Patel, Sanjay
Charlie, Jean-Damien
Robert Davids
Golek, Julian
Kay, david
Ronald Negtel
Patel, Sanjay
Application Number:
JP2002559413A
Publication Date:
October 01, 2008
Filing Date:
December 19, 2001
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07D403/12; C12N9/99; A61K31/435; A61K31/4439; A61K31/444; A61K31/4709; A61K31/4725; A61K31/496; A61K31/501; A61K31/506; A61K31/513; A61K31/517; A61K31/519; A61K31/53; A61K31/5377; A61K31/541; A61K31/55; A61K45/00; A61P1/00; A61P3/08; A61P3/10; A61P3/14; A61P5/00; A61P5/18; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/06; A61P13/12; A61P15/00; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/12; C07D401/14; C07D403/14; C07D405/14; C07D407/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D473/16; C07D487/04; C07D491/04; C07D493/04; C07D495/04; C07D498/04; C07D513/04; C07D521/00; A61K; A61P; C07D
Foreign References:
| WO2000021955A1 | ||||
| WO2002018346A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita