Title:
動脈血流不足による組織損傷処置用医薬組合せ
Document Type and Number:
Japanese Patent JP4181875
Kind Code:
B2
Abstract:
This invention relates to human medicine, and particularly with a pharmaceutical combination made up with Epidermal Growth Factor (EGF) and a Growth Hormone secretagogue hexapeptide (GHRP); being useful to prevent tissue damages due to blood flow suppression as to enhance tissue repair following ischaemic damages. The aforementioned combination may be applied as a single pharmaceutical composition. Alternatively, an individual may also receive both EGF and GHRP in a separate manner but within a single therapeutic regime to enhance cellular survival when organs are subjected to blood flow deprivation for a critical period of time. This combination attenuates reactive oxygen species (ROS) formation and its associated cytotoxicity. It is useful to promote cellular survival when tissues or organs are exposed to prolonged ischaemic periods. The combination may be used as a prophylactic agent in those subjects prone to multiple organ failure (MOF) such as burn victims, multiple trauma patients, hypoxic neonates, acute respiratory distress syndrome, and necrotizing enterocolitis patients.
Inventors:
Berlanga Acosta, Holge
Gillen Nieto, Gerard, Enrique
Garcia del Barco Herrera, Diana
Fernandez Masso, Julio, Raul
Estrada Garcia, Mario, Pablo
Gillen Perez, Isabel
Suarez Alba, Jose
Martinez, Rodriguez, Rebecca
Gillen Nieto, Gerard, Enrique
Garcia del Barco Herrera, Diana
Fernandez Masso, Julio, Raul
Estrada Garcia, Mario, Pablo
Gillen Perez, Isabel
Suarez Alba, Jose
Martinez, Rodriguez, Rebecca
Application Number:
JP2002554116A
Publication Date:
November 19, 2008
Filing Date:
December 17, 2001
Export Citation:
Assignee:
Centro in the Any Area Energy Biotechnology
International Classes:
A61K38/00; A61K38/08; A61K38/18; A61K38/22; A61K38/25; A61K38/27; A61P7/00; A61P9/10; A61P43/00
Domestic Patent References:
| JP2083334A |
Foreign References:
| US5360790 |
Other References:
Endocrinologia Japonica,1991年,Vol.38,No.1,p15-21
Life Science,1991年,Vol.48,No.23,p2283-2288
Life Science,1990年,Vol.47,No.1,p29-36
Journal of Clinical Endocrinology and Metabolism,1995年,Vol.80,No.1,p190-194
Journal of Clinical Endocrinology and Metabolism,1994年,Vol.79,No.2,p470-479
Clinical Endocrinology,1993年,Vol.39,No.4,p403-408
Annals of Surgery,2000年,Vol.231,No.4,p577-586
Annals of Surgery,2000年,Vol.231,No.2,p246-252
Life Science,1991年,Vol.48,No.23,p2283-2288
Life Science,1990年,Vol.47,No.1,p29-36
Journal of Clinical Endocrinology and Metabolism,1995年,Vol.80,No.1,p190-194
Journal of Clinical Endocrinology and Metabolism,1994年,Vol.79,No.2,p470-479
Clinical Endocrinology,1993年,Vol.39,No.4,p403-408
Annals of Surgery,2000年,Vol.231,No.4,p577-586
Annals of Surgery,2000年,Vol.231,No.2,p246-252
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
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