Title:
蛋白代謝機能を有する人工腎臓およびその作製方法
Document Type and Number:
Japanese Patent JP4181877
Kind Code:
B2
Abstract:
The present invention provides an intra-corporeal artificial kidney having a function of metabolizing protein and a method of constructing the same. The present invention provides an intra-corporeal artificial kidney having a function of metabolizing protein which comprises, as constituent elements, a sponge sheet with an angiogenesis promoting growth factor-containing hydrogel injected therein as well as cells with megalin, which is an endocytosis receptor playing a central role in the protein metabolizing function of proximal tubular cells, as expressed on the surface of the cells, and a method of constructing an intra-corporeal artificial kidney having the function of metabolizing protein which comprises using a sponge sheet with an angiogenesis promoting growth factor-containing hydrogel injected therein as well as cells with megalin expressed on the surface.
Inventors:
Yasuhiko Tabata
Ryohiko Saito
Fumitake Shimojo
Shigeo Koyoshi
Kenji Yamashita
Ryohiko Saito
Fumitake Shimojo
Shigeo Koyoshi
Kenji Yamashita
Application Number:
JP2002588876A
Publication Date:
November 19, 2008
Filing Date:
May 17, 2002
Export Citation:
Assignee:
Yasuhiko Tabata
Ryohiko Saito
Kaneka Corporation
Ryohiko Saito
Kaneka Corporation
International Classes:
A61F2/02; A61L27/00; A61L27/38; A61L27/52; A61M1/14; A61M1/36; A61P1/16; C12M3/00; C12N5/08; C12N11/02
Domestic Patent References:
| JP9503941A |
Foreign References:
| WO1998009582A1 |
Other References:
Yasuhiko Tabata,Yoshito Ikada,Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. ,Biomaterials,米国,1999年11月,Volume20,Issue22,p.2169-2175
Jorg-Robert Leheste,外10名,Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria,American Journal of Pathology,米国,1999年10月,volume155,No.4,p.1361-1370
Jorg-Robert Leheste,外10名,Megalin Knockout Mice as an Animal Model of Low Molecular Weight Proteinuria,American Journal of Pathology,米国,1999年10月,volume155,No.4,p.1361-1370
Attorney, Agent or Firm:
Yasuo Yasutomi