Title:
血液脳関門輸送を調節するための組成物および方法
Document Type and Number:
Japanese Patent JP4202250
Kind Code:
B2
Abstract:
This invention provides conjugates of therapeutic or active agents with melanotransferrin or with other ligands of a melanotransferrin receptor, melanotransferrin receptor modulators, and related compositions and methods for modulating blood-brain barrier transport by providing methods of screening and selecting such conjugates, ligands, and modulators in vitro and in vivo, and methods of use of such conjugates, modulators and ligands in diagnosis and the treatment of diseases, including particularly diseases of the central nervous system or lysosomal storage diseases.
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Inventors:
Beribeau, richard
Demure, michel
Yang, joseph
Kennard, Malcolm El.
Gabular, Reinhard
Demure, michel
Yang, joseph
Kennard, Malcolm El.
Gabular, Reinhard
Application Number:
JP2003515208A
Publication Date:
December 24, 2008
Filing Date:
July 25, 2002
Export Citation:
Assignee:
Biomarine Pharmaceutical Incorporated
International Classes:
G01N33/50; A61K45/00; A61K47/48; A61P7/02; A61P9/10; A61P25/00; A61P35/00; A61P43/00; C07K14/79; C07K16/40; C07K19/00; C12N5/08; C12Q1/02; G01N33/15; G01N33/68
Foreign References:
| US5981194 | ||||
| WO2001059459A1 |
Other References:
Brain Research Reviews,1998年,vol.27,p.257-267
The Journal of Biological Chemistry,1999年,vol.274, no.11,p.7011-7017
The Journal of Biological Chemistry,1999年,vol.274, no.11,p.7011-7017
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita