細胞障害抑制活性を有するペプチドおよび当該細胞障害抑制活性を有するペプチドのスクリーニング方法 - Institute for Chemistry and Serum Therapy

Title:

細胞障害抑制活性を有するペプチドおよび当該細胞障害抑制活性を有するペプチドのスクリーニング方法

Document Type and Number:

Japanese Patent JP4226909

Kind Code:

B2

Abstract:

A peptide fragment or a series of peptide fragments containing one or more selenocysteine that has a lowered toxicity than selenocystine and that exhibits a cytotoxicity-inhibitory activity. The peptide fragment or a series of peptide fragments according to the present invention has preferably the amino acid sequence from 260th to 362nd amino acid residues from the C-terminal of selenoprotein P, or said amino acid sequence with one or several amino acid residues therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. A screening method for a peptide fragment having the cytotoxicity-inhibitory activity is also provided.

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Inventors:

Masaki Hirashima
Takeshi Naruse
Hiroaki Maeda
Shuei Nozaki
Takeshi Goto
Katsuhiko Akiyama
Hattori Wataru

Application Number:

JP2002589677A

Publication Date:

February 18, 2009

Filing Date:

May 10, 2002

Export Citation:

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Assignee:

Institute for Chemistry and Serum Therapy
Hisamitsu Pharmaceutical Co., Ltd.

International Classes:

C12N15/09; C07K14/47; G01N33/50; C12Q1/02; C12Q1/28; G01N33/15

Foreign References:

WO2000031131A1

Other References:

PNAS,1993年,Vol.90,pp.537-541
J. Neurosci.,1998年,Vol.18, No.21,pp.8682-8691

Attorney, Agent or Firm:

Kyousei Tamura
Yushiro Tsuboi
Nagatoshi Shinagawa

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