Title:
ピラゾール誘導体およびその医学的使用
Document Type and Number:
Japanese Patent JP4234786
Kind Code:
B1
Abstract:
Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R1 and R3 independently represent H, C1-6alkyl, C3-8cycloalkyl, or halogen; R2 represents C1-6alkyl, CF3 or aryl; a represents 1 or 2; R4, R5, R7 and R8 independently represent H, C1-6alkyl, C1-6alkyloxy, CN or halogen, or R4 and R5, or R7 and R8, together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH2 or O; R6 represents H, CN or halo provided that, when X represents N, R6 is absent. The compounds are useful for treating endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), or chronic pelvic pain syndrome.
Inventors:
Paul Anthony Bradley
Kevin Nail Duck
Patrick Stefan Johnson
Sarah Elizabeth Skelat
Kevin Nail Duck
Patrick Stefan Johnson
Sarah Elizabeth Skelat
Application Number:
JP2008539519A
Publication Date:
March 04, 2009
Filing Date:
October 26, 2006
Export Citation:
Assignee:
Pfizer Limited
International Classes:
C07D231/18; A61K31/415; A61P15/00; C07D401/12
Domestic Patent References:
| JP63313784A |
Other References:
Jones, David G. et al.,Discovery of non-steroidal mifepristone mimetics: Pyrazoline-based PR antagonists,Bioorganic & Medicinal Chemistry Letters,2005年,15(13),PP.3203-3206
Attorney, Agent or Firm:
High Hoji Koji
Junko Miyazawa
Noh four
Yoshinobu Murofushi
Junko Miyazawa
Noh four
Yoshinobu Murofushi