Title:
造血幹細胞または造血前駆細胞の増殖または生存を支持し得るポリペプチドおよびそれをコードするDNA
Document Type and Number:
Japanese Patent JP4251983
Kind Code:
B2
Abstract:
A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
Inventors:
Mitsuo Nishikawa
Dormanac, Ladgetty.
Lavat, Ivan
Lee, juy
Tan, Tom Wye.
Stachet-Crane, Bargit
Dormanac, Ladgetty.
Lavat, Ivan
Lee, juy
Tan, Tom Wye.
Stachet-Crane, Bargit
Application Number:
JP2003503664A
Publication Date:
April 08, 2009
Filing Date:
June 11, 2002
Export Citation:
Assignee:
Kyowa Hakko Kirin Co., Ltd.
International Classes:
C12N15/09; A61K38/22; A61P7/06; A61P43/00; C07K14/47; C07K14/475; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/0789; C12N5/10; C12N15/12; A61K38/00
Domestic Patent References:
| JP2005503108A |
Foreign References:
| WO1998008869A1 | ||||
| WO1999003980A1 |
Other References:
生化学辞典第3版 (1998) p.806-807
細胞, 36[2] (2004) p.20-21
Ann N Y Acad Sci., 938 (2001 June) p.109-116
BIO Clinica, 15[6] (2000) p.56-58
Blood, 89[12] (1997) p.4337-4347
Proc Atl Acad Aci., 94 (1997) p.4011-4016
Stem Cells, 15 (1997) p.334-339
Blood, 92[6] (1998) p.2032-2040
Blood, 90[10] (1997) p.483a
細胞, 36[2] (2004) p.20-21
Ann N Y Acad Sci., 938 (2001 June) p.109-116
BIO Clinica, 15[6] (2000) p.56-58
Blood, 89[12] (1997) p.4337-4347
Proc Atl Acad Aci., 94 (1997) p.4011-4016
Stem Cells, 15 (1997) p.334-339
Blood, 92[6] (1998) p.2032-2040
Blood, 90[10] (1997) p.483a
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Hidemi Matsukura
Tsutomu Toyama
Hidemi Matsukura
Tsutomu Toyama