Title:
ジチオカルバマート誘導体を使用した癌の治療方法
Document Type and Number:
Japanese Patent JP4268801
Kind Code:
B2
Abstract:
Dithiocarbamate, particularly tetraethylthiuram disulfide, and thiocarbamate anions thereof, strongly inhibit the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin. A method is presented for using tetraethylthiuram disulfide to reduce tumor growth, and to potentiate the effect of other anticancer agents.
Inventors:
Kennedy, Thomas Preston
Application Number:
JP2002531975A
Publication Date:
May 27, 2009
Filing Date:
October 04, 2001
Export Citation:
Assignee:
Charlotte-Mecklenburg Hospital Authority, Doing Business as Carolinas Medical Center
International Classes:
A61K31/27; A61K33/24; A61P9/00; A61K31/28; A61K31/285; A61K31/295; A61K31/30; A61K31/315; A61K31/325; A61K33/04; A61K33/242; A61K33/243; A61K33/26; A61K33/30; A61K33/32; A61K33/34; A61K33/36; A61K33/38; A61K38/20; A61K38/21; A61K38/44; A61K45/06; A61P9/10; A61P11/06; A61P29/00; A61P35/00; A61P43/00
Other References:
European Journal of Medicinal Chemistry,1986年,21(3),pp.261-265
Polyhedron,1999年,18,pp.2827-2837
Journal of Inorganic Biochemistry,1988年,33,pp.1-9
Inorganica Chimica Acta,1989年,166,135-140
Anti-Cancer Drug Design,1988年,3,pp.205-216
Journal of Inorganic Biochemistry,1990年,38(1),pp.81-93
Toxicology Letters,1993年,66,pp.97-104
Polyhedron,1999年,18,pp.2827-2837
Journal of Inorganic Biochemistry,1988年,33,pp.1-9
Inorganica Chimica Acta,1989年,166,135-140
Anti-Cancer Drug Design,1988年,3,pp.205-216
Journal of Inorganic Biochemistry,1990年,38(1),pp.81-93
Toxicology Letters,1993年,66,pp.97-104
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo