Title:
MCHアンタゴニストとして使用されるアリールピペリジンおよびビアリールピペリジン
Document Type and Number:
Japanese Patent JP4280073
Kind Code:
B2
Abstract:
In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration or one or more of diseases associated with the MCH receptor. An illustrative inventive compound is shown below:
Inventors:
Hobbes, Douglas W.
Guo, Tao
Hunter, Russell Sea.
Guo, Fuitsung
Bab, Susie Dee.
Xiao, Yue Fei
Guo, Tao
Hunter, Russell Sea.
Guo, Fuitsung
Bab, Susie Dee.
Xiao, Yue Fei
Application Number:
JP2002580938A
Publication Date:
June 17, 2009
Filing Date:
April 10, 2002
Export Citation:
Assignee:
Pharmacopea Drug Discovery, Incorporated
International Classes:
C07D211/26; A61K31/438; A61K31/4433; A61K31/445; A61K31/4525; A61K31/454; A61K31/4545; A61K45/00; A61P3/04; A61P5/14; A61P43/00; C07D211/32; C07D211/34; C07D211/64; C07D401/06; C07D401/10; C07D405/04; C07D405/10; C07D405/12; C07D471/10
Domestic Patent References:
| JP10510511A | ||||
| JP11507324A | ||||
| JP8048669A | ||||
| JP6504980A | ||||
| JP54009281A | ||||
| JP43011456B1 | ||||
| JP42002708B1 |
Foreign References:
| WO2001007050A1 | ||||
| WO2000025786A1 | ||||
| WO2000006545A1 | ||||
| WO1999065494A1 | ||||
| WO1993022310A1 | ||||
| FR1501151B1 | ||||
| FR1477152B1 | ||||
| US3278541 | ||||
| FR1381445B1 | ||||
| US2538107 | ||||
| GB640168B |
Other References:
NAGARATHNAM,D. et al,Design and synthesis of novel α1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia,Journal of Medicinal Chemistry,1998年,Vol.41, No.26,p.5320-5333
STEVENSON,G.I. et al,4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure-Activity Relationships and in Vivo Activity,Journal of Medicinal Chemistry,1998年,Vol.41, No.23,p.4623-4635
Chemical Abstracts,1987年,Vol.106,584,18327d
Chemical Abstracts,1981年,Vol.94,634,192067n
Chemical Abstracts,1978年,Vol.89,595,43033t
ELLIOTT,J.M. et al,Serine derived NK1 antagonists 2: a pharmacophore model for arylsulfonamide binding,Bioorganic & Medicinal Chemistry Letters,1998年,Vol.8, No.14,p.1851-1856
BAKER,H.F. et al,Further consideration of the learning impairment after aceperone in the marmoset: effects of the drug on shape and color discrimination and on an alternation task,Pharmacology, Biochemistry and Behavior,1983年,Vol.18, No.5,p.701-4
ONG,H.H. et al,Novel tetracyclic spiropiperidines. 3. 1-Arylspiro[indoline-3,4'-piperidine]s as potential antidepressants,Journal of Medicinal Chemistry,1983年,Vol.26, No.7,p.981-6
DEGRAW,J.I. et al,Histamine releasers. III. Dibasic acid amides of 4-phenyl-4-aminomethylpiperidines,Journal of Medicinal Chemistry,1967年,Vol.10, No.2,p.174-7
Preparation of substituted 4-(aminomethyl)piperidines and their straight chain analogs,Chemical Abstracts,1948年,Vol.42,1270-1271,1270f-i,1271a-d
STEVENSON,G.I. et al,4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure-Activity Relationships and in Vivo Activity,Journal of Medicinal Chemistry,1998年,Vol.41, No.23,p.4623-4635
Chemical Abstracts,1987年,Vol.106,584,18327d
Chemical Abstracts,1981年,Vol.94,634,192067n
Chemical Abstracts,1978年,Vol.89,595,43033t
ELLIOTT,J.M. et al,Serine derived NK1 antagonists 2: a pharmacophore model for arylsulfonamide binding,Bioorganic & Medicinal Chemistry Letters,1998年,Vol.8, No.14,p.1851-1856
BAKER,H.F. et al,Further consideration of the learning impairment after aceperone in the marmoset: effects of the drug on shape and color discrimination and on an alternation task,Pharmacology, Biochemistry and Behavior,1983年,Vol.18, No.5,p.701-4
ONG,H.H. et al,Novel tetracyclic spiropiperidines. 3. 1-Arylspiro[indoline-3,4'-piperidine]s as potential antidepressants,Journal of Medicinal Chemistry,1983年,Vol.26, No.7,p.981-6
DEGRAW,J.I. et al,Histamine releasers. III. Dibasic acid amides of 4-phenyl-4-aminomethylpiperidines,Journal of Medicinal Chemistry,1967年,Vol.10, No.2,p.174-7
Preparation of substituted 4-(aminomethyl)piperidines and their straight chain analogs,Chemical Abstracts,1948年,Vol.42,1270-1271,1270f-i,1271a-d
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita