Title:
非毒性の粘膜アジュバント
Document Type and Number:
Japanese Patent JP4283889
Kind Code:
B2
Abstract:
A non-toxic mucosal adjuvant is provided which may be admixed with further antigens to provide a vaccine administrable to mucosal surfaces in organisms including man. Preferably, the non-toxic mucosal adjuvant is a detoxified mutant of a bacterial ADP-ribosylating toxin, optionally comprising one or more amino acid additions, deletions or substitutions.
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Inventors:
La Poli, Reno
Application Number:
JP51730095A
Publication Date:
June 24, 2009
Filing Date:
December 22, 1994
Export Citation:
Assignee:
Chiron Sochieta A Responsor Billita Limitata
International Classes:
A61K39/39; A61K39/395; C07K14/245
Foreign References:
| WO1993013202A1 | ||||
| WO1992019265A1 |
Other References:
Vaccine, 1993年 9月, Vol.11, No.12, pp.1179-1184
Vaccine Research, 1993年, Vol.2, No.1, pp.1-10
The Journal of Biochemical Chemistry, 1990年, Vol.265, No.36, pp.22520-22525
Infection and Immunity, 1991年, Vol.59, No.9, pp.2870-2879
Vaccine Research, 1993年, Vol.2, No.1, pp.1-10
The Journal of Biochemical Chemistry, 1990年, Vol.265, No.36, pp.22520-22525
Infection and Immunity, 1991年, Vol.59, No.9, pp.2870-2879
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita