Title:
緻密にした核酸および細胞へのデリバリ
Document Type and Number:
Japanese Patent JP4285766
Kind Code:
B2
Abstract:
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
Inventors:
Hanson, Richard, W
Perrals, Joseph, Sea
Felcol, Thomas, W, Junior
Perrals, Joseph, Sea
Felcol, Thomas, W, Junior
Application Number:
JP52482695A
Publication Date:
June 24, 2009
Filing Date:
March 23, 1995
Export Citation:
Assignee:
Ohio University
International Classes:
A61K48/00; C12N15/09; A61K31/70; A61K38/00; A61K38/28; A61K39/395; A61K47/48; A61P3/06; A61P7/00; A61P7/04; A61P9/10; A61P37/00; A61P43/00; C07H21/00; C07H21/04; C07K14/705; C07K16/18; C07K19/00; C12N9/64; C12N15/87
Foreign References:
| WO1994005624A1 | ||||
| WO1993007283A1 |
Other References:
Somatic Cell and Molecular Genetics, 18(6), p559-569, 1992
Biochemistry, 32, p7143-7151, 1993
Biochemistry, 32, p7143-7151, 1993
Attorney, Agent or Firm:
Eiko Funahashi