Title:
インドール誘導体、その製造方法および用途
Document Type and Number:
Japanese Patent JP4292742
Kind Code:
B2
Abstract:
Indole derivatives represented by formula (I): (wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an active ingredient. Since the compounds of formula (I) binds to and are antagonistic to a DP receptor, they are useful in for the prevention and/or treatment of diseases, for example, allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma, food allergy, etc., systemic mastocytosis; disorders due to systemic mastocyte activation, anaphylactic shock, bronchoconstriction, urticaria, eczema, etc.), diseases accompanied with itching (atopic dermatitis, urticaria, etc.), secondary diseases caused by behaviors (scratching behaviors, beating, etc.) (cataract, retinal detachment, inflammation, infection, sleep disorder, etc.), inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis, and the like.
Inventors:
Kazuhiko Torisu
Kaoru Kobayashi
Fumio Nanbu
Kaoru Kobayashi
Fumio Nanbu
Application Number:
JP2001565338A
Publication Date:
July 08, 2009
Filing Date:
March 08, 2001
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
C07D209/08; A61K31/404; C07D209/12; A61K31/4155; A61K31/4178; A61K31/422; A61K31/423; A61K31/427; A61K31/4439; A61K31/454; A61K31/4709; A61K31/497; A61K31/498; A61K31/5377; A61K31/538; A61K31/5383; A61K31/5415; A61P1/04; A61P7/02; A61P9/10; A61P11/06; A61P17/00; A61P17/04; A61P25/20; A61P27/02; A61P27/12; A61P27/14; A61P29/00; A61P31/10; A61P37/08; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D411/12; C07D413/12; C07D417/12; C07D498/04
Domestic Patent References:
| JP9176162A |
Other References:
J.Org.Chem.,1999年,64,9731-9734
Attorney, Agent or Firm:
Kunihisa Landlord