Title:
2-フェニルベンゾチアゾリン誘導体
Document Type and Number:
Japanese Patent JP4296345
Kind Code:
B2
Abstract:
To provide a κ-opioid receptor agonist composed of a 2-phenylbenzothazoline derivative.
The present invention relates to the κ-opioid receptor agonist composed of a compound containing a chemical structure represented by formula (I) [wherein R represents an alkyl group having an amino group as a substituent group; R
COPYRIGHT: (C)2004,JPO
Inventors:
Tokai Maki
Takahiro Honda
Niwa Masashi
Yaeko Tsukahara
Kenichi Fujimura
Shinichi Kono
Takahiro Honda
Niwa Masashi
Yaeko Tsukahara
Kenichi Fujimura
Shinichi Kono
Application Number:
JP2003089657A
Publication Date:
July 15, 2009
Filing Date:
March 28, 2003
Export Citation:
Assignee:
Santen Pharmaceutical Co., Ltd.
International Classes:
C07D277/66; A61K31/428; A61P17/04; A61P25/04; A61P29/00; A61P43/00; C07D417/12
Domestic Patent References:
| JP58046079A | ||||
| JP59067276A | ||||
| JP60139679A | ||||
| JP61083175A | ||||
| JP62221679A | ||||
| JP62221680A | ||||
| JP8231399A |
Foreign References:
| US4479949 |
Other References:
YAMAMOTO, K.,"Novel calcium antagonists. Synthesis and structure-activity relationship studies of benzothiazoline derivatives",Journal of Medicinal Chemistry,1988年,Vol.31, No.5,pp.919-930
FUJITA, M.,"Synthesis and calcium antagonistic activity of (+)-(R)- and (-)-(S)-3-acetyl-2-[5-methoxy-2-[4-[N-methyl-N-(3,4,5- trimethoxyphenethyl)amino]butoxy]phenyl]benzothiazoline hydrochloride" ,Chemical & Pharmaceutical Bulletin,1990年,Vol.38, No.4,pp.936-941
WAY, E. L.,"Review of revues",ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY,1992年,Vol.32,pp.9-23
BEN-SRETI,M.M. et al,Effects of elevated calcium and calcium antagonists on 6,7-benzomorphan-induced analgesia,Eur J Pharmacol,1983年,Vol.90, No.4,p.385-91
FUJITA, M.,"Synthesis and calcium antagonistic activity of (+)-(R)- and (-)-(S)-3-acetyl-2-[5-methoxy-2-[4-[N-methyl-N-(3,4,5- trimethoxyphenethyl)amino]butoxy]phenyl]benzothiazoline hydrochloride" ,Chemical & Pharmaceutical Bulletin,1990年,Vol.38, No.4,pp.936-941
WAY, E. L.,"Review of revues",ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY,1992年,Vol.32,pp.9-23
BEN-SRETI,M.M. et al,Effects of elevated calcium and calcium antagonists on 6,7-benzomorphan-induced analgesia,Eur J Pharmacol,1983年,Vol.90, No.4,p.385-91
Attorney, Agent or Firm:
Norihiko Hibi
Einosuke Kishimoto
Akira Watanabe
Kiyosue Yasuko
Einosuke Kishimoto
Akira Watanabe
Kiyosue Yasuko
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