Title:
複素環式芳香族キノリン化合物およびPDE10阻害剤としてのその使用
Document Type and Number:
Japanese Patent JP4302762
Kind Code:
B2
Abstract:
The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.
Inventors:
Patrick Robert Vergeest
Christopher John Herare
Dennis Jay Hoover
John Mycle Humphrey
Christopher John Herare
Dennis Jay Hoover
John Mycle Humphrey
Application Number:
JP2007549961A
Publication Date:
July 29, 2009
Filing Date:
December 22, 2005
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07D401/14; A61K31/444; A61K31/4709; A61K31/498; A61K31/501; A61K31/506; A61K31/517; A61K31/519; A61P3/04; A61P9/10; A61P15/08; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/36; A61P43/00; C07D413/14; C07D471/04; C07D487/04
Domestic Patent References:
| JP6239859A | ||||
| JP7508502A | ||||
| JP2002284766A | ||||
| JP2008501776A | ||||
| JP2002363103A |
Foreign References:
| WO2004002484A1 | ||||
| WO1993007124A1 |
Other References:
Victor Segarra,Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds,Bioorganic & Medicinal Chemistry Letters,1998年,Vol.8, No.5,pp.505-510
Attorney, Agent or Firm:
Yoshinobu Murofushi