Title:
システインプロテアーゼの可逆的阻害剤として有効な新規なニトリル
Document Type and Number:
Japanese Patent JP4309251
Kind Code:
B2
Abstract:
Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases and pathological conditions exacerbated by these proteases such as, but not limited to, osteoporosis, rheumatoid arthritis, multiple sclerosis, asthma and other autoimmune diseases, Alzheimer's disease, atherosclerosis. Also disclosed are processes for making such novel compounds.
Inventors:
Hicky Eugene Earl
Beccary younes
Pateil Usha Earl
Spero Dennis M
Thomas david es
Young Eric Earl Earl
Beccary younes
Pateil Usha Earl
Spero Dennis M
Thomas david es
Young Eric Earl Earl
Application Number:
JP2003503617A
Publication Date:
August 05, 2009
Filing Date:
June 05, 2002
Export Citation:
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
International Classes:
C07C255/29; C07D295/18; A61K31/277; A61K31/343; A61K31/35; A61K31/381; A61K31/40; A61K31/404; A61K31/4436; A61K31/445; A61K31/45; A61K31/454; A61K31/47; A61K31/472; A61K31/495; A61K31/496; A61K31/5375; A61K31/5377; A61K31/55; A61P1/00; A61P1/02; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/04; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/28; A61P29/00; A61P33/02; A61P33/06; A61P35/00; A61P37/00; A61P37/02; A61P37/08; A61P43/00; C07C253/20; C07C253/30; C07C269/04; C07C269/06; C07C271/12; C07C271/28; C07C271/30; C07C271/34; C07C271/38; C07D207/16; C07D211/66; C07D211/90; C07D213/84; C07D215/38; C07D217/06; C07D223/06; C07D223/10; C07D295/185; C07D295/20; C07D295/205; C07D295/215; C07D307/85; C07D309/14; C07D333/70; C07D401/06; C07D401/12; C07D403/06; C07D405/06; C07D409/14; C07D417/12
Domestic Patent References:
| JP6211766A | ||||
| JP5286937A | ||||
| JP7502758A | ||||
| JP2004535422A | ||||
| JP2003512463A | ||||
| JP2002537293A | ||||
| JP2001522862A |
Foreign References:
| GB1396941B | ||||
| GB1396942B | ||||
| US4021224 |
Other References:
Biochimica et Biophysica Acta, General Subjects,1993年,1158(3),p.264-272
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama