Title:
ストレプトマイセス属に属するネマデクチン生産能を有する菌株、該菌株を用いるネマデクチンの製造法
Document Type and Number:
Japanese Patent JP4310750
Kind Code:
B2
Abstract:
In the present invention, a recombination of gene groups of nemadectin aglycon biosynthesis is performed for obtaining C-13 hydroxylnemadectin, to which sugar groups can be attached, and a production strain which produces C-13 hydroxylnemadectin is produced. Further, C-13 glycosylnemadectin producing strain is prepared by introducing aveBI-BVIII genes involving glycosidation of avermectin and biosynthesis of oleandrose. As described, C-13 hydroxylnemadectin and C-13 glycosidated nemadectin can be obtained effectively by using the producing strain prepared by means of the molecular genetic technology, and improvement in the biological activity thereof can be expected.
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Inventors:
Satoshi Omura
Osamu Ikeda
Yumiko Ogasawara
Osamu Ikeda
Yumiko Ogasawara
Application Number:
JP2005500741A
Publication Date:
August 12, 2009
Filing Date:
June 11, 2003
Export Citation:
Assignee:
Kitasato Institute
International Classes:
C12N1/21; C12N1/20; C12N15/09; C12N15/52; C12P17/18; C12P19/62; C12R1/465
Domestic Patent References:
| JP2003033188A |
Other References:
CARTER G.T.,J.ANTIBIOT.,1988年 4月25日,V41 N4,P519-529
池田 治生,蛋白質 核酸 酵素,日本,1998年,V43 N9,P1265-1277
池田 治生,化学と生物,日本,1996年,V34 N11,P761-771
池田 治生,バイオサイエンスとインダストリー,日本,2001年,V59 N8,P530-533
MACNEIL D.J.,IND.MICROORG.,1993年,P245-254
池田 治生,蛋白質 核酸 酵素,日本,1998年,V43 N9,P1265-1277
池田 治生,化学と生物,日本,1996年,V34 N11,P761-771
池田 治生,バイオサイエンスとインダストリー,日本,2001年,V59 N8,P530-533
MACNEIL D.J.,IND.MICROORG.,1993年,P245-254
Attorney, Agent or Firm:
Kazunori Kobayashi