新規ビタミンD構造類似体

Japanese Patent JP4312183

B2

The present invention relates to analogues of vitamin D, which lack the combined presence of the trans-fused six-membered C-ring and of five-membered D-ring, but still possess a central part consisting of a substituted chain of five atoms, atoms which correspond to positions 8, 14, 13, 17 and 20 of vitamin D, and at the ends of which are connected, at position 20 a structural moiety representing part of the side-chain of vitamin D or of an analogue of vitamin D, and at position 8 the DELTA (5,7)-diene moiety connected to the A-ring of the active 1-alpha-hydroxy metabolite or of an established vitamin D analogue, to their preparation process, to pharmaceutical preparations comprising these compounds and to their use in medicine.

Roger BOUILLON
Mauriz Vandewale
Pierre Jean de Clerco

JP2005253297A

August 12, 2009

September 01, 2005

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K.U.LEUVEN RESEARCH & DEVELOPMENT
Roger BOUILLON
Universiteit Gent

A61K31/59; A61K31/045; C07C401/00; A61K31/047; A61K31/075; A61P3/10; A61P3/14; A61P5/00; A61P5/18; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P17/10; A61P17/14; A61P19/02; A61P19/10; A61P25/00; A61P29/00; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/00; A61P37/04; A61P37/06; A61P43/00; C07C35/22; C07C35/27; C07C43/188; C07C45/28; C07C47/192; C07C47/198; C07C47/347; C07C47/36; C07C47/37; C07C49/242; C07C49/517; C07C49/523; C07C49/687; C07C49/743; C07C49/755; C07C57/26; C07C59/01; C07C61/13; C07C69/18; C07C69/21; C07C69/757; C07C255/47; C07B53/00; C07D301/14; C07D303/32

JP9500117A
JP4505332A
JP3505330A
JP5140090A
JP61501146A

DE3913310A

Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi

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