スルホンアミド-置換された化合物、それらの製法、医薬または診断薬としてのそれらの使用およびそれらを含有する医薬製剤

Japanese Patent JP4317601

B2

N-(Bicyclic aryl or heteroaryl)-sulphonamide or sulphamide derivatives of formula (I) and their salts are new: X = O, S, SO, SO2, NR7, CR'8R"8 or C=O; R7 = H or -CaH2a-R9, where one CH2 is optionally replaced by O, CH=CH, C IDENTICAL C, CO, CO2, OCO, S, SO, SO2, NR10 or CONR10; R10 = H or A; a = 0-8; R9 = H, CF3, C2F5, C3F7, 3-8 C cycloalkyl, NMe2, NEt2, 1-piperidyl, pyrrolidino, morpholino or 4-methyl-piperazin-1-yl, pyridyl, thienyl, imidazolyl or phenyl (the latter four all optionally substituted by 1 or 2 F, Cl, Br, I, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); or R1+R7 = bond; R'8 = H, CF3, C2F5, C3F7, 1-6 C alkyl or phenyl (optionally substituted by 1 or 2 F, Cl, Br, I, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); R"8 = H, A, OR10, CO2R10 or COR10; R10 = H or A; or R'8+R1 or R"8+R1 = bond if Y = N; Y = N or CR11; R11 = H or A; R1, R2 = H, CF3, C2F5, C3F7, F, Cl, OMe, 1-6 C alkyl or phenyl (optionally substituted by 1 or 2 F, Cl, Br, I, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); or CR1R2 = 2-10 C alkylene chain; R3 = R12-CnH2n-N(R13)- or R12-CnH2n-, where one CH2 of CnH2n is optionally replaced by O, CO, S, SO, SO2 or R'10; R'10 = H, Me or Et; R12 = H, Me, 3-8 C cycloalkyl, CF3, C2F5 or C3F7; n = 0-10; R13 = H or 1-6 C alkyl; or R12+R13 = bond if n ≥ 3; or R3+R4 = 3-8 C alkylene chain, where one CH2 is optionally replaced by O, CO, S, SO, SO2 or NR'10; R4 = R14-CrH2r-, where one CH2 of CrH2r is optionally replaced by O, CH=CH, C IDENTICAL C, CO, CO2, OCO, S, SO, SO2, NR"10 or CONR"10; R"10 = H or A; R14 = Me, CF3, C2F5, C3F7, 3-8 C cycloalkyl, OH, CO2H, NR23R24, 1-piperidyl, 1-pyrrolidinyl, 4-morpholinyl or 4-methylpiperazin-1-yl, pyridyl, thienyl, imidazolyl or phenyl (the latter four all optionally substituted by 1 or 2 F, Cl, Br, I, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); R23, R24 = H or A; or NR23R24 = (CH2)k, where one CH2 is optionally replaced by O, S, NH, NMe or N(CH2Ph); k = 4 or 5; r = 0-20; R5+R6 = -CR15=CR16CR17=CR18-, -CR15=CR16CR17=N-, -CR15=CR16N=CR18-, -CR15=N-CR17=N-, -CR15=NN=CR18-, -N=CR16CR17=N- or -SCR15=CR16-, all bonded in either direction; R15-R18 = H, F, Cl, Br, I, 1-5C alkyl, 3-8 C cycloalkyl, CN, CF3, C2F5, C3F7, N3, NO2, -Z-CsH2s-R22, thienyl or phenyl (optionally substituted by 1 or 2 F, Cl, Br, I, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); Z = O, CO, CO2, OCO, S, SO, SO2, SO2O, SO2NR'"10, NR'"10 or CONR'"10; R'"10 = H or A; s = 0-6; R22 = H, CF3, C2F5, C3F7, 3-8 C cycloalkyl, NR19R20, CO2R21, 1-piperidyl, 1-pyrrolidinyl, 4-morpholinyl or 4-methylpiperazin-1-yl, pyridyl, thienyl, imidazolyl, quinolyl, isoquinolyl or phenyl (the latter six all optionally substituted by 1 or 2 F, Cl, Br, I, CF3, NO2, CN, NH2, OH, Me, Et, OMe, NMe2, SO2NH2, SO2Me and NHSO2Me); R19, R20 = H or A; or NR19R20 = (CH2)k, where one CH2 is optionally replaced by O, S, NH, NMe or N(CH2Ph); R21 = H or A; and A = 1-3 C alkyl; provided that Y is not CR11 if X = O.

Joachim Brendel
Hans Johen Lang
Uwe Gerlach
Klaus Vuitman

JP34546997A

August 19, 2009

December 15, 1997

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Hoechst Gesellschaft Mito Beschlenktel Haftung

C07D215/42; A61K31/33; C07D239/22; A61K31/35; A61K31/352; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/505; A61K31/535; A61K31/536; A61K31/54; A61K31/545; A61P1/00; A61P1/04; A61P9/00; A61P43/00; C07D207/325; C07D211/14; C07D213/06; C07D213/75; C07D217/22; C07D239/94; C07D241/04; C07D265/06; C07D265/16; C07D265/20; C07D277/20; C07D295/08; C07D295/12; C07D311/68; C07D311/70; C07D333/10; C07D335/00; C07D417/04; A61K31/4706; A61P19/02; A61P29/00

JP6345754A
JP4243852A
JP5097824A
JP8003144A

Pfluegers Archiv,1995年,Vol.429, No.4,p.517-530

Chika Takagi
Tatsuo Sato
Kosuke Nishimura

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