骨吸収の阻害剤およびビトロネクチン受容体アンタゴニストとしての新規なイミノ誘導体

Japanese Patent JP4334029

B2

Aromatic compounds of formula R1YABDEF'CR<4>R<5)R<7>)p(CH2)q-R<10> (I) and their salts are new. A = bond, Z, 1-8C alkanediyl, NR<2>C(Q)NR<2>, NR<2>C(Q)Q, NR<2>S(O)nNR<2>, NR<2>S(O)nO, NR<2>-S(O)n, 3-12C cycloalkanediyl, C IDENTICAL C, NR<2>C(O), C(O)NR<2>, 5-14C arylene-C(O)NR<2>, O, S(O)n, 5-14C arylene, CO, 5-14C arylene-CO, NR<2>, SO2NR<2>, CO2, CR<2>=CR<3> or 5-14C arylene-S(O)n (all optionally mono- or disubstituted by 1-8C alkanediyl, i.e. e.g. 1-8C alkanediyl-CONR<2>-1-8C alkanediyl, 1-8C alkanediyl-CONR<2> or CONR<2>-1-8C alkanediyl); Z = NR<2>-N=CR<2>, N=CR<2> or CR<2>=N; Q = O or S; B = direct bond, 1-8C alkanediyl, CR<2>=CR<3> or C IDENTICAL C (all optionally mono- or disubstituted by 1-8C alkanediyl) or a divalent residue of a 5- or 6-membered saturated or unsaturated ring containing 1 or 2 N atoms (optionally mono- or disubstituted by 1-6C alkyl or Q); D, F' = bond, 1-8C alkanediyl, or Z, Q, NR<2>, CONR<2>, NR<2>CO, NR<2>C(Q)NR<2>, OC(O), C(O)O, CQ, S(O), S(O)2, S(O)2NR<2>, NR<2>S(O), NR<2>S(O)2, CR<2>=CR<3>, C IDENTICAL C or CH(OH) (all optionally mono- or disubstituted by 1-8C alkanediyl); E = 6-membered aromatic group optionally containing 1-4 N atoms (optionally mono- to tetra-substituted by R<2>, R<3>, F, Cl, Br, I, NO2 and OH); Y = bond or NR<2>; R<1> = NR<2>CR<2)<=NR<2>), C(=NR<2>)NR<2>R<3>, NR<2>C(=NR<2>)NR<2>R<3>, or a 4-10 membered monocyclic or polycyclic aromatic or non-aromatic ring optionally containing 1-4 N, O and/or S atoms (optionally substituted by 1 or more R<12>-R<15>); R<2>, R<3> = H, 1-10C alkyl (optionally substituted by 1 or more F), 3-12C cycloalkyl, 3-12C cycloalkyl-(1-8C)alkanediyl, 5-14C aryl, 5-14C aryl-(1-8C)alkanediyl, NH2, R<9>NR<8>OR<8>, R<9>OR<8>, R<9>COOR<8>, R<9>-5-14C arylene-R<8>, R<9>N(R<8>)2, R<9>NR<8>1-8C alkanediyl-OH, R<9>CON(R<8>)2, R<9>NR<8>C(O)R<8>, R<9>C(O)R<8>, C(=NR<8>)N(R<8>)2 or (1-18C)alkylcarbonyloxy(1-6)alkanediyloxycarbonyl; R<4>-R<7> = H, F, OH, 1-8C alkyl, 3-12C cycloalkyl, 3-12C-cycloalkyl(1-8C)alkanediyl, R<9>QR<8>, R<9>OCOR<8>, R<9>COOR<8>, R<9>-5-14C arylene-R<8>, etc.; R<8> = H, 1-8C alkyl (optionally substituted by 1 or more F), 3-12C cycloalkyl, 1-8C-alkanediyl-3-12C cycloalkyl, 5-14C aryl or 1-8C alkanediyl-5-14C aryl; R<9> = direct bond or 1-8C alkanediyl; R<10> = C(Q)R<11>, S(O)nR<11>, P(O)(R<11>)n or a 4-8 membered saturated or unsaturated heterocycle containing 1-4 N, O and/or S atoms; R<11> = OH, 1-8C alkoxy, 1-8C alkanediyl-5-14C-aryl, 5-14C aryloxy, 1-4C alkanediyloxycarbonyl1-8C alkylcarbonyloxy, 5-14C aryl-1-8C alkanediylcarbonyloxy-1-6C alkanediyloxy, NH2, NH(1-8C alkyl), N(1-8C alkyl)2, 5-14C aryl-1-8C alkanediylamino, 1-8C dialkylaminocarbonylmethyleneoxy, 5-14C aryl-1-8C dialkylaminocarbonylmethyleneoxy, 5-14C arylamino or the residue of a L- or D-amino acid; R<12>-R<15> = H, 1-10C alkyl (optionally substituted by 1 or more F), 3-12C cycloalkyl, etc.; n = 1 or 2; p, q = 0 or 1; provided that at least 1 of A, D and F' = Z.

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Fork Mar Werner
Johen Knole
Hans Ulrich Schewterz
Jean-Francois Gourvet
Denny Carniart
Thomas Lichyard Garden
Robert McDowell
Robert Morris Pittei
Cearah Katherine Bowery

JP19715597A

September 16, 2009

July 23, 1997

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Hoechst Gesellschaft Mito Beschlenktel Haftung
Genentech Inc.

C07C229/04; A61K31/19; C07D233/52; A61K31/197; A61K31/415; A61K31/4164; A61K31/445; A61P3/00; A61P9/00; A61P13/02; A61P15/00; A61P19/00; A61P19/08; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07C251/02; C07D211/18; C07D233/54; C07D233/66; C07D257/04

JP8504194A
JP8502486A
JP10501222A
JP10504808A
JP656662A
JP656663A
JP10504807A

Chika Takagi

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