Title:
MAOB阻害剤としてのピロリドン誘導体
Document Type and Number:
Japanese Patent JP4335142
Kind Code:
B2
Abstract:
The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
Inventors:
Iding, hans
Yoridon, Genese
Krummenner Hael, Daniela
Rodriguez-Sarmiento, Rosa Maria
Thomas, Andrew William
Wilds, Beat
Vostel, Wolfgang
Wyler, Rene
Yoridon, Genese
Krummenner Hael, Daniela
Rodriguez-Sarmiento, Rosa Maria
Thomas, Andrew William
Wilds, Beat
Vostel, Wolfgang
Wyler, Rene
Application Number:
JP2004537121A
Publication Date:
September 30, 2009
Filing Date:
September 18, 2003
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D207/28; A61K31/4015; A61P25/16; A61P25/28; C07D207/26; C07D207/273; C07D207/277; C07D401/04; C07B53/00
Domestic Patent References:
| JP55051064A |
Foreign References:
| FR2500831A1 |
Other References:
DING, C. Z., et al.,Transformation of Heterocyclic Reversible Monoamine Oxidase-B Inactivators into Irreversible Inactivators by N-Methylation,Journal of Medicinal Chemistry,1993年,36(23),p. 3606-3610
SILVERMAN, R. B., et al.,Chemical Model for a Mechanism of Inactivation of Monoamine Oxidase by Heterocyclic Compounds. Electronic Effects on Acetal Hydrolysis,Journal of the American Chemical Society,1993年,115(11),p. 4571-4576
SILVERMAN, R. B., et al.,Chemical Model for a Mechanism of Inactivation of Monoamine Oxidase by Heterocyclic Compounds. Electronic Effects on Acetal Hydrolysis,Journal of the American Chemical Society,1993年,115(11),p. 4571-4576
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda