Title:
グリコペプチド抗生物質モノマー誘導体
Document Type and Number:
Japanese Patent JP4377953
Kind Code:
B2
Abstract:
A compound of the formula:
a pharmaceutically acceptable salt or solvate thereof, wherein, R A is formula:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ-x 1 -Ar 1 -X 2 -Y-X 3 -Ar 2
wherein, X 1 , X 2 and X 3 are independently,
1) a single bond,
2) a heteroatom-containing group selected from the group consisting of -N=, =N-, -NR 1 - wherein R 1 is hydrogen or lower alkyl, -O-, -S-, -SO- and -SO 2 -, or a linkage thereof,
or
3) optionally substituted alkylene or alkenylene optionally interrupted by one or more same or different said heteroatom-containing group;
Y is -NR 2 CO-, -CONR 2 - wherein R 2 is hydrogen or lower alkyl, or a group of the formula:
wherein R 3 is alkylene; and
Ar 1 and Ar 2 are independently, a carbocycle or heterocycle which is optionally substituted and may have an unsaturated bond;
R B is -OH or -OR 6 wherein R 6 is optionally substituted alkyl that may comprise a heteroatom-containing group;
R C is hydrogen or optionally substituted alkyl that may comprise a heteroatom-containing group; and
R D is hydrogen or lower alkyl,
excluding the case that Ar 1 is phenylene; Y is -NR 2 CO-; and Ar 2 is monofluorophenyl.
Inventors:
Arimoto Hirokazu
Road force
Yoshinori Yamano
Tatsuro Amono
Osamu Yoshida
Iwaya Tsutomu
Yutaka Yoshida
Kato Issei
Kenji Morimoto
Kayo Yasoshima
Road force
Yoshinori Yamano
Tatsuro Amono
Osamu Yoshida
Iwaya Tsutomu
Yutaka Yoshida
Kato Issei
Kenji Morimoto
Kayo Yasoshima
Application Number:
JP2008298383A
Publication Date:
December 02, 2009
Filing Date:
November 21, 2008
Export Citation:
Assignee:
Nagoya University
Shionogi Pharmaceutical Co., Ltd.
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07K7/06; A61K38/00; A61P31/04
Domestic Patent References:
| JP7258289A | ||||
| JP2001163898A |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Yushiro Tsuboi
Masahiro Nitta
Samejima Mutsumi
Yushiro Tsuboi
Masahiro Nitta