7-キノリニル-3,5-ジヒドロキシヘプト-6-エン酸エステルの製造法

Title:

7-キノリニル-3,5-ジヒドロキシヘプト-6-エン酸エステルの製造法

Document Type and Number:

Japanese Patent JP4380160

Kind Code:

B2

Abstract:

A method for preparing a 7-quinolynyl-3,5-dihydroxyhept-6-enoate useful as an intermediate for pharmaceuticals, in high yield and in high purity, is presented. It is a method for preparing a 7-quinolinyl-3,5-dihydroxyhept-6-enoate represented by the formula (IV): (wherein R represents an alkyl group or an aryl group), characterized in that a compound represented by the formula (I): (wherein R is as defined above), or a compound represented by the formula (II): (wherein R is as defined above), is reduced by sodium borohydride in the presence of a boron compound represented by the formula (III): R'OBR"2 (wherein R' and R" represent independently an alkyl group), and then the resultant reaction mixture is treated with an aqueous solution of hydrogen peroxide.

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Inventors:

Kenichi Tokunaga
Seimi Ozawa
Kenji Suzuki

Application Number:

JP2002579439A

Publication Date:

December 09, 2009

Filing Date:

March 22, 2002

Export Citation:

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Assignee:

Nissan Chemical Industry Co., Ltd.

International Classes:

C07D215/14

Domestic Patent References:

JP8092217A
JP1279866A
JP61040243A

Other References:

Chemical Letters,1980年,p.1415-1418

Attorney, Agent or Firm:

Kenji Izumina
Toshiharu Ogawa
Ryozo Yamamoto

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