Title:
フルオロキノロンカルボン酸の改良された製造方法
Document Type and Number:
Japanese Patent JP4380963
Kind Code:
B2
Abstract:
Fluoroquinolonecarboxylic acids can be prepared by hydrolysis of the corresponding C1-C4-alkyl esters with addition of water, acetic acid, and sulfuric acid using a drastically reduced amount of sulfuric acid if, relative to 1 mol of C1-C4-alkyl fluoroquinolonecarboxylate, less than 30 g of sulfuric acid are employed, the reaction mixture is heated to reflux for 0.5 to 8 hours, then a mixture of acetic acid, C1-C4-alkyl acetate, C1-C4-alkyl alcohol, and optionally water is distilled off, and finally the fluoroquinolonecarboxylic acid prepared is isolated.
Inventors:
Norbert Louis
Hans Panxkus
Hans Panxkus
Application Number:
JP2002040170A
Publication Date:
December 09, 2009
Filing Date:
February 18, 2002
Export Citation:
Assignee:
LANXESS Deutschland Gamebecher
International Classes:
C07D215/56
Domestic Patent References:
| JP7285941A | ||||
| JP8325196A | ||||
| JP4009352A | ||||
| JP9143169A | ||||
| JP10114740A | ||||
| JP10067766A |
Other References:
社団法人 日本化学会 編,新実験化学講座 14 有機化合物の合成と反応II,丸善株式会社,1977年,p.930-932
Attorney, Agent or Firm:
Patent business corporation Odashima patent office