Title:
軸索成長のNOGOのレセプターを仲介とした妨害
Document Type and Number:
Japanese Patent JP4383869
Kind Code:
B2
Abstract:
Disclosed are NgR proteins and biologically active Nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the Nogo and NgR protein. Also disclosed are peptides which block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.
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Inventors:
Stephen M. Stritt Matter
Application Number:
JP2003534444A
Publication Date:
December 16, 2009
Filing Date:
October 04, 2002
Export Citation:
Assignee:
YALE UNIVERSITY
International Classes:
C12N15/09; G01N33/50; A61K31/713; A61K38/00; A61K38/17; A61K39/395; A61K45/06; A61K48/00; A61P25/00; A61P25/28; A61P43/00; C07K14/705; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02; G01N33/15
Other References:
Nature, vol. 409, pages 341-346 (Jan. 2001)
J. Neurosci., vol. 22, pages 8876-8883 (2002)
J. Neurosci., vol. 22, pages 8876-8883 (2002)
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga