Title:
アルキルエーテル誘導体またはその塩
Document Type and Number:
Japanese Patent JP4398247
Kind Code:
B2
Abstract:
Alkyl ether derivatives (I) are new. Alkyl ether derivatives of formula (I) and their salts are new. [Image] R 1, R 2 : H, halo, optionally substituted alkyl, aryl, aralkyl, alkoxy, aryloxy, alkylthio, arylthio, alkenyl, alkenyloxy, alkylsulfonyl, arylsulfonyl, carbamoyl, heterocyclyl, NO 2, oxo or optionally protected hydroxy, amino or carboxyl; R 3 : optionally substituted alkylamino or optionally protected amino or hydroxy; A : 5 or 6 membered heteroaryl or benzene; m, n : 1-6; and p : 1-3. ACTIVITY : Calcium-Antagonist. MECHANISM OF ACTION : Neuroprotective; CNS-Gen. In nerve regeneration models in SD rats 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol (Ia) hydrochloric acid salt administered at 1 mg/kg/day orally for 13 days increased regeneration by 186% compared to a control.
Inventors:
Akito Saito
Noboru Iwakami
Tamotsu Takamatsu
Noboru Iwakami
Tamotsu Takamatsu
Application Number:
JP2003538163A
Publication Date:
January 13, 2010
Filing Date:
October 18, 2002
Export Citation:
Assignee:
Toyama Chemical Co., Ltd.
International Classes:
C07D409/12; A61K31/397; A61K31/40; A61K31/4025; A61K31/4525; A61K31/4535; A61P25/00; A61P25/02; A61P25/28; A61P43/00; C07D207/12; C07D405/12
Domestic Patent References:
| JP8268883A | ||||
| JP1156973A | ||||
| JP11263773A | ||||
| JP8511783A |
Foreign References:
| WO1997030703A1 | ||||
| WO1997011054A1 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Katsunori Ando
Yukihiro Ikeda
Hajime Asamura
Katsunori Ando
Yukihiro Ikeda