Title:
トロンビンの安定化手段および組成物
Document Type and Number:
Japanese Patent JP4399615
Kind Code:
B2
Abstract:
The present invention is to provide a means for the stabilization of thrombin and a stabilized thrombin-containing composition having a good reproducibility of the measurement. There are provided a means for the stabilization of thrombin, characterized in that, effective amount (s) of one or more which is/are selected from calcium ion, surfactant and protein is/are contained and a stabilized thrombin-containing composition as well. There are also provided a means for the stabilization of thrombin where an effective amount of a water-soluble organic acid is jointly used in addition to the above and a stabilized thrombin-containing composition as well. There is further provided a thrombin-containing composition having an extremely high measurement reproducibility using thrombin and stabilizer for thrombin where one or more high-molecular polysaccharides or synthetic polymers is/are contained in the above-mentioned stabilized thrombin-containing composition.
Inventors:
Masahiro Okuda
Kikukawa Norihiro
Kikukawa Norihiro
Application Number:
JP2001526919A
Publication Date:
January 20, 2010
Filing Date:
September 22, 2000
Export Citation:
Assignee:
Sysmex Corporation
International Classes:
C12N9/96; C12N9/74
Domestic Patent References:
| JP56039782A | ||||
| JP8512058A | ||||
| JP7134129A | ||||
| JP7265075A | ||||
| JP62269689A | ||||
| JP61034097A | ||||
| JP11500619A |
Foreign References:
| WO1999018994A1 |
Attorney, Agent or Firm:
Takashi Shoji