Title:
キラルなオキサゾール-アリールプロピオン酸誘導体及びPPARアゴニストとしてのこれらの使用
Document Type and Number:
Japanese Patent JP4414886
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula (I) wherein wherein R1, R2, R3, R4, R5, R6 and n are as described herein. The compounds of the present invention can be used as medicaments for the treatment and/or prevention of diseases which are modulated by PPARalpha and/or PPARgamma agonists. Examples of such diseases are diabetes, particularly non-insulin dependent diabetes mellitus, elevated blood pressure, increased lipid and cholesterol levels, atherosclerotic diseases, metabolic syndrome, endothelial dysfunction, procoagulant state, dyslipidemia, polycystic ovary syndrome, inflammatory diseases (such as e.g. crown disease, inflammatory bowel disease, collitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as e.g. Alzheimer's disease or impaired/improvable cognitive function) and proliferative diseases.
Inventors:
Bingeri, Alfred
Boehringer, Marx
Greetter, uwe
Hilpelt, Hans
Iltu, Georges
Melchi, Hans-Peter
Marx, Meyer
Mall, peter
Ricklin, Fabian
Boehringer, Marx
Greetter, uwe
Hilpelt, Hans
Iltu, Georges
Melchi, Hans-Peter
Marx, Meyer
Mall, peter
Ricklin, Fabian
Application Number:
JP2004540787A
Publication Date:
February 10, 2010
Filing Date:
October 06, 2003
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D263/32; A61K31/421; A61P3/00; A61P3/06; A61P3/10; A61P9/10; A61P29/00; A61P43/00
Domestic Patent References:
| JP2001261612A |
Foreign References:
| WO2002016331A1 | ||||
| WO2000008002A1 |
Other References:
LIU, K. G., et al.,Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activi,Bioorganic & Medicinal Chemistry Letters,2001年,11(17),p. 2385-2388
LOHRAY, B. B., et al.,(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic Acid [(-)DRF2725]: A Dual PPAR Agonist,Journal of Medicinal Chemistry,2001年,44(16),p. 2675-2678
LOHRAY, B. B., et al.,(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic Acid [(-)DRF2725]: A Dual PPAR Agonist,Journal of Medicinal Chemistry,2001年,44(16),p. 2675-2678
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda